Minchenko A G, Tron'ko N D
Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):70-5.
Subcellular distribution of 3H-corticosterone and its metabolites in liver subcellular fractions of intact and adrenalectomized rats was studied. Corticosterone metabolites were found in the cytosol, microsomes, nuclei and mitochondria of rat liver cells in intact and adrenalectomized rats. The content of metabolites was different in all subcellular fractions. In adrenalectomized rats it was enhanced in the liver microsomes, nuclei and mitochondria which might be accounted for by a raised retention of metabolites by the endoplasmic reticulum membranes, mitochondria and nuclei.
研究了完整大鼠和肾上腺切除大鼠肝脏亚细胞组分中3H-皮质酮及其代谢产物的亚细胞分布。在完整大鼠和肾上腺切除大鼠的大鼠肝细胞的胞质溶胶、微粒体、细胞核和线粒体中均发现了皮质酮代谢产物。所有亚细胞组分中代谢产物的含量均不同。在肾上腺切除大鼠中，肝脏微粒体、细胞核和线粒体中的代谢产物含量增加，这可能是由于内质网膜、线粒体和细胞核对代谢产物的保留增加所致。
