[Metabolism of 3H-corticosterone in the liver cells of intact and adrenalectomized rats].

Subcellular distribution of 3H-corticosterone and its metabolites in liver subcellular fractions of intact and adrenalectomized rats was studied. Corticosterone metabolites were found in the cytosol, microsomes, nuclei and mitochondria of rat liver cells in intact and adrenalectomized rats. The content of metabolites was different in all subcellular fractions. In adrenalectomized rats it was enhanced in the liver microsomes, nuclei and mitochondria which might be accounted for by a raised retention of metabolites by the endoplasmic reticulum membranes, mitochondria and nuclei.