Tron'ko N D, Minchenko A G
Probl Endokrinol (Mosk). 1985 Jul-Aug;31(4):64-8.
A study was made of the metabolism of 3H-cortisol in the kidney, spleen and thymus cytosol and microsomes of intact and adrenalectomized rats. Cortisone and tetrahydrocortisone were found to be the main cortisol metabolites in the kidney cytosol and microsomes in these two groups of animals. In intact rats, the tetrahydrocortisone level in the kidney cytosol was hizher than that in the microsome fraction. After adrenalectomy opposite changes were noted: the tetrahydrocortisone level was increased in the microsome fraction and significantly lowered in the cytosol which might be accounted for by a decreased rate of cortisol metabolism and a raised retention of tetrahydrocortisone by the endoplasmic reticulum membranes. Cortisone and tetrahydrocortisone turned out to be the main metabolites of cortisol the rat spleen and thymus cytosol but their content was much lower than that in the kidneys.
对完整大鼠和肾上腺切除大鼠的肾脏、脾脏及胸腺的胞液和微粒体中3H-皮质醇的代谢情况进行了研究。在这两组动物的肾脏胞液和微粒体中，可的松和四氢皮质醇被发现是主要的皮质醇代谢产物。在完整大鼠中，肾脏胞液中的四氢皮质醇水平高于微粒体部分。肾上腺切除后出现了相反的变化：微粒体部分的四氢皮质醇水平升高，而胞液中的显著降低，这可能是由于皮质醇代谢速率降低以及内质网膜对四氢皮质醇的保留增加所致。可的松和四氢皮质醇被证明是大鼠脾脏和胸腺胞液中皮质醇的主要代谢产物，但其含量远低于肾脏中的含量。
