• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

原发性不明的恶性黑色素瘤患者的诊疗方法

Approach to Patients with Malignant Melanoma of Unknown Primary Origin.

作者信息

Sirvan Selami Serhat, İhsan Eren Hikmet, Kurt Yazar Sevgi, Günenç Ali Can, Yeşilada Ayşin Karasoy, Irmak Fatih, Tuncel Deniz

机构信息

Department of Plastic Reconstructive and Aesthetic Surgery, Health Sciences University Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Department of Plastic Reconstructive and Aesthetic Surgery, Hatay State Hospital, Hatay, Turkey.

出版信息

Sisli Etfal Hastan Tip Bul. 2019 Mar 22;53(2):125-131. doi: 10.14744/SEMB.2019.52333. eCollection 2019.

DOI:10.14744/SEMB.2019.52333
PMID:32377070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7199841/
Abstract

OBJECTIVES

Although malignant melanoma accounts for 3% of skin cancers, it is responsible for 75% of deaths associated with skin cancer. In our study, all melanoma cases diagnosed and treated at our clinic were retrospectively reviewed, and the cases of unknown primary origin among them were examined in detail in terms of diagnosis and treatment.

METHODS

The patients with malignant melanoma treated at the inpatient services of our clinic between January 1991 and April 2017 were retrospectively screened in the records. These patients were evaluated for age, sex, tumor type, Breslow depth, metastasis, and treatment. Among these patients, four cases of unknown primary origin were examined in detail.

RESULTS

During January 1991 and April 2017, 173 patients received inpatient care for malignant melanoma at our clinic. As regards to the melanoma subtypes, nodular type in 45 patients, acral lentiginous type in 43 patients, superficial spreading type in 63 patients, lentigo maligna melanoma in 15 patients, subungual type in 7 patients, and either unidentified melanoma or other subtypes in 10 patients were identified.

CONCLUSION

The ideal treatment of a patient with melanoma is multidisciplinary, with plastic surgery having a central role.

摘要

目的

尽管恶性黑色素瘤仅占皮肤癌的3%，但却导致了75%的皮肤癌相关死亡。在我们的研究中，对在我们诊所诊断和治疗的所有黑色素瘤病例进行了回顾性分析，并对其中原发灶不明的病例在诊断和治疗方面进行了详细检查。

方法

回顾性筛查1991年1月至2017年4月期间在我们诊所住院治疗的恶性黑色素瘤患者的病历记录。对这些患者的年龄、性别、肿瘤类型、Breslow厚度、转移情况及治疗方法进行评估。在这些患者中，对4例原发灶不明的病例进行了详细检查。

结果

1991年1月至2017年4月期间，173例患者在我们诊所接受了恶性黑色素瘤的住院治疗。黑色素瘤亚型方面，45例为结节型，43例为肢端雀斑样痣型，63例为浅表扩散型，15例为恶性雀斑样痣黑色素瘤，7例为甲下型，10例为未明确的黑色素瘤或其他亚型。

结论

黑色素瘤患者的理想治疗是多学科的，整形手术起着核心作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/9c4c794c5daa/MBSEH-53-125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/be1d626cfc5c/MBSEH-53-125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/1ba0b08fa60f/MBSEH-53-125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/3f9eb40ee506/MBSEH-53-125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/70ef80312b08/MBSEH-53-125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/9c4c794c5daa/MBSEH-53-125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/be1d626cfc5c/MBSEH-53-125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/1ba0b08fa60f/MBSEH-53-125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/3f9eb40ee506/MBSEH-53-125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/70ef80312b08/MBSEH-53-125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/7199841/9c4c794c5daa/MBSEH-53-125-g005.jpg

相似文献

1
Approach to Patients with Malignant Melanoma of Unknown Primary Origin.原发性不明的恶性黑色素瘤患者的诊疗方法
Sisli Etfal Hastan Tip Bul. 2019 Mar 22;53(2):125-131. doi: 10.14744/SEMB.2019.52333. eCollection 2019.
2
A retrospective histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage I. The consequences of a reclassification of the original group of lentigo maligna melanomas.一项对669例临床I期原发性皮肤恶性黑色素瘤的回顾性组织学研究。原恶性雀斑样痣黑色素瘤组重新分类的结果。
Acta Pathol Microbiol Scand A. 1979 Jul;87A(4):255-60. doi: 10.1111/j.1699-0463.1979.tb00050.x.
3
[Clinical and histopathological characteristics of malignant melanoma cases seen at "Dr. Manuel Gea González" General Hospital].["墨西哥墨西哥城“曼努埃尔·吉亚·冈萨雷斯博士”综合医院收治的恶性黑色素瘤病例的临床及组织病理学特征"]
Gac Med Mex. 2008 May-Jun;144(3):219-23.
4
Acral lentiginous melanoma versus lentigo maligna melanoma among Iraqi patients.伊拉克患者中肢端雀斑样痣黑色素瘤与恶性雀斑样痣黑色素瘤的对比
Saudi Med J. 2007 Jan;28(1):105-7.
5
Acral lentiginous melanoma of the oral cavity.口腔肢端雀斑样痣性黑色素瘤
Head Neck Surg. 1983 Jan-Feb;5(3):257-62. doi: 10.1002/hed.2890050311.
6
Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure.根据形态学特征和紫外线暴露情况对韩国患者黑色素瘤亚型的比较
Ann Dermatol. 2014 Aug;26(4):485-90. doi: 10.5021/ad.2014.26.4.485. Epub 2014 Jul 31.
7
Clinicopathological Profile of a Cohort of Patients With Malignant Melanoma in the United Kingdom.英国一组恶性黑色素瘤患者的临床病理特征
Cureus. 2023 Jun 2;15(6):e39874. doi: 10.7759/cureus.39874. eCollection 2023 Jun.
8
Malignant melanoma: basic approach to clinicopathologic correlation.恶性黑色素瘤：临床病理相关性的基本方法
Mayo Clin Proc. 1997 Mar;72(3):267-72. doi: 10.4065/72.3.267.
9
Acral lentiginous melanoma.肢端雀斑样痣黑色素瘤。
Arch Dermatol. 1980 Jul;116(7):773-6.
10
[Primary malignant melanoma of the skin. Retrospective study of 375 cases. Clinical aspects and histology].[皮肤原发性恶性黑色素瘤。375例回顾性研究。临床特征与组织学]
Med Clin (Barc). 1990 Feb 24;94(7):246-9.

引用本文的文献

1
Axillary Lymph Node Malignant Melanoma of Unknown Primary Origin: A Case Report From Japan.原发灶不明的腋窝淋巴结恶性黑色素瘤：来自日本的一例报告
Cureus. 2024 Oct 18;16(10):e71802. doi: 10.7759/cureus.71802. eCollection 2024 Oct.
2
Comprehensive Literature Review on Melanoma of Unknown Primary Site Triggered by an Intriguing Case Report.由一份引人入胜的病例报告引发的关于原发部位不明黑色素瘤的综合文献综述
Diagnostics (Basel). 2024 Oct 3;14(19):2210. doi: 10.3390/diagnostics14192210.
3
Melanoma of Unknown Primary With Metastasis to the Brain: A Case Report and Review of the Literature.

本文引用的文献

1
Malignant Melanoma: Beyond the Basics.恶性黑色素瘤：基础之外
Plast Reconstr Surg. 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367.
2
Lymphoscintigraphy and sentinel lymph node biopsy, in cutaneous melanoma staging and treatment decisions.淋巴闪烁显像和前哨淋巴结活检在皮肤黑色素瘤分期及治疗决策中的应用
Hell J Nucl Med. 2015 May-Aug;18(2):146-51. doi: 10.1967/s002449910210. Epub 2015 Jul 20.
3
Managing malignant melanoma.恶性黑素瘤的治疗。
原发灶不明的黑色素瘤伴脑转移：一例报告及文献复习
Cureus. 2024 Aug 16;16(8):e67022. doi: 10.7759/cureus.67022. eCollection 2024 Aug.
4
A Unique Case of High-Grade Dedifferentiated Melanoma Without a Known Primary Site.一例罕见的无已知原发部位的高级别去分化黑色素瘤病例。
Cureus. 2024 Aug 15;16(8):e66951. doi: 10.7759/cureus.66951. eCollection 2024 Aug.
5
Metastatic Malignant Melanoma of the Gastrointestinal Tract: Too Dark to be Seen?胃肠道转移性恶性黑色素瘤：因颜色过深而难以发现？
GE Port J Gastroenterol. 2022 Oct 28;30(1):1-3. doi: 10.1159/000527210. eCollection 2023 Jan.
Plast Reconstr Surg. 2013 Sep;132(3):446e-460e. doi: 10.1097/PRS.0b013e31829ad411.
4
Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma.不明原发灶黑色素瘤具有与皮肤日光暴露性黑色素瘤一致的突变特征。
Pigment Cell Melanoma Res. 2013 Nov;26(6):852-60. doi: 10.1111/pcmr.12153. Epub 2013 Aug 23.
5
Metastatic melanoma from unknown primary presenting as dorsal midbrain syndrome.以中脑背侧综合征为表现的原发性不明的转移性黑色素瘤。
Optom Vis Sci. 2012 Dec;89(12):e112-7. doi: 10.1097/OPX.0b013e3182771698.
6
Cancer statistics, 2010.癌症统计数据，2010 年。
CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7.
7
Malignant melanoma of unknown primary site. To make the long story short. A systematic review of the literature.原发灶不明的恶性黑色素瘤。长话短说。对文献的系统回顾。
Crit Rev Oncol Hematol. 2011 May;78(2):112-26. doi: 10.1016/j.critrevonc.2010.04.007. Epub 2010 May 31.
8
Melanoma of unknown primary site: a 33-year experience at the Turin Melanoma Centre.原发灶不明的黑色素瘤：都灵黑色素瘤中心的 33 年经验。
Melanoma Res. 2010 Jun;20(3):227-32.
9
Melanoma with an unknown primary--a case series.原发灶不明的黑色素瘤——病例系列。
J Plast Reconstr Aesthet Surg. 2010 Dec;63(12):2071-80. doi: 10.1016/j.bjps.2010.02.028. Epub 2010 Mar 23.
10
Current concepts of metastasis in melanoma.黑色素瘤转移的当前概念。
Expert Rev Dermatol. 2008 Oct;3(5):569-585. doi: 10.1586/17469872.3.5.569.