Talmaç Mehmet Ali, Görgel Mehmet Akif, Birsel Sema Ertan, Sönmez Mehmet Mesut, Özdemir Hacı Mustafa
Department of Orthopaedics, Health Sciences University Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
Department of Orthopaedics, Istanbul Private Medicine Hospital, Istanbul, Turkey.
Sisli Etfal Hastan Tip Bul. 2019 Jun 21;53(2):137-142. doi: 10.14744/SEMB.2018.73604. eCollection 2019.
This study aimed to analyze the efficacy of single-dose tranexamic acid (TA) 20 mg/kg preoperatively to reduce blood loss in patients undergoing total knee replacement (TKR).
A total of 387 patients (82 males, 305 females) undergoing TKR between January 2014 and December 2018 were included in the study. The T + group was administrated intravenous (iv) TA 20 mg/kg 20 min before the skin incision. We determined perioperative blood loss, the amount of drainage postoperative 24 h, the amount of drainage after postoperative 24-48 h, total volume of drains, total volume of blood loss, postoperative hemoglobin and hematocrit levels, and amount of total blood transfusion.
In terms of demographic data, no statistically significant difference was observed between the groups. Perioperative blood loss and total volume of blood loss was found statistically higher in T - group compared to T + group. Postoperatively, the mean hemoglobin and hematocrit levels of T - group were statistically significantly lower than T + group.
A single 20 mg/kg iv TA administration before TKR reduces bleeding during surgery and within 24 h postoperatively.
本研究旨在分析术前单剂量静脉注射20mg/kg氨甲环酸（TA）对全膝关节置换术（TKR）患者减少失血的疗效。
本研究纳入了2014年1月至2018年12月期间接受TKR的387例患者（82例男性，305例女性）。T+组在皮肤切口前20分钟静脉注射20mg/kg TA。我们测定了围手术期失血量、术后24小时引流量、术后24 - 48小时引流量、引流总量、总失血量、术后血红蛋白和血细胞比容水平以及总输血量。
在人口统计学数据方面，两组之间未观察到统计学上的显著差异。与T+组相比，T - 组的围手术期失血量和总失血量在统计学上更高。术后，T - 组的平均血红蛋白和血细胞比容水平在统计学上显著低于T+组。
TKR术前单次静脉注射20mg/kg TA可减少手术期间及术后24小时内的出血。
