醛脱氢酶3B2基因多态性与结直肠癌易感性相关。
ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility.
作者信息
Gao Zhi-Gang, Yang Yong, Han Xiao-Feng, Wang Yun-Lei, Wang Zhen-Jun
机构信息
Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
出版信息
J Oncol. 2020 Jan 4;2020:5179635. doi: 10.1155/2020/5179635. eCollection 2020.
Colorectal cancer (CRC) is the 5 leading cancer in China. Alcohol consumption has been reported to be one of the risk factors of CRC. However, it remains unclear whether genetic variants of alcohol metabolic genes are associated with CRC risk. In this study, we tested the coding variants in the alcohol metabolic genes and the risk of CRC, by using 485 cases and 516 controls. A total of 16 germline coding variants in 10 alcohol metabolic genes were genotyped. We identified that rs3741178 in ALDH3B2 was significantly associated with CRC risk with odds ratio being 2.13 (95% CI: 1.24-3.68, =0.0064). Further functional annotation suggested that this variant may damage the protein function of ALDH3B2. Our results suggested that ALDH3B2 in the alcohol metabolism pathway contributed to the development of CRC, which may contribute to the prevention of this disease in the future.
结直肠癌（CRC）是中国排名第五的常见癌症。据报道，饮酒是结直肠癌的风险因素之一。然而，尚不清楚酒精代谢基因的遗传变异是否与结直肠癌风险相关。在本研究中，我们通过485例病例和516例对照，检测了酒精代谢基因中的编码变异与结直肠癌风险。对10个酒精代谢基因中的16个种系编码变异进行了基因分型。我们发现，ALDH3B2基因中的rs3741178与结直肠癌风险显著相关，比值比为2.13（95%置信区间：1.24 - 3.68，P = 0.0064）。进一步的功能注释表明，该变异可能损害ALDH3B2的蛋白质功能。我们的结果表明，酒精代谢途径中的ALDH3B2促成了结直肠癌的发生，这可能有助于未来对该疾病的预防。
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