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一份初步报告显示，多杀菌素和氟虫腈能够使常见臭虫致倦库蚊失去活动能力。

A Preliminary Report Showing Spinosad and Fluralaner Are Able to Incapacitate Cimex lectularius L., the Common Bed Bug.

作者信息

Sheele Johnathan M

机构信息

Emergency Medicine, Mayo Clinic, Jacksonville, USA.

出版信息

Cureus. 2020 Apr 3;12(4):e7529. doi: 10.7759/cureus.7529.

DOI:10.7759/cureus.7529
PMID:32377477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7198093/
Abstract

L., the common bed bug, is a hematophagous human ectoparasite. The veterinary drugs, spinosad and fluralaner, were studied for their ability to incapacitate when administered in a blood meal using an artificial feeding system under laboratory conditions. Tested drug doses were based on the reported peak blood levels in animals given the drugs. Spinosad at doses 1,000 ng/mL or higher resulted in 75% or greater bed bug incapacitation (defined as death or immobility). Fluralaner at doses 500 ng/mL or higher had 100% bed bug incapacitation. Both drugs were significantly more effective than controls at these doses (< 0.001).

摘要

温带臭虫是一种吸食人血的体表寄生虫。在实验室条件下，使用人工饲养系统，研究了兽药多杀菌素和氟虫腈在血粉中给药时使臭虫丧失活动能力的效果。测试的药物剂量基于给动物用药后报告的血药峰值水平。剂量为1000纳克/毫升或更高的多杀菌素导致75%或更多的臭虫丧失活动能力（定义为死亡或不动）。剂量为500纳克/毫升或更高的氟虫腈使臭虫100%丧失活动能力。在这些剂量下，两种药物均比对照组显著更有效（<0.001）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/422adabdbca3/cureus-0012-00000007529-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/a9d2d088a6c6/cureus-0012-00000007529-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/cf04d501d945/cureus-0012-00000007529-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/bafcb459432f/cureus-0012-00000007529-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/4f495159e25c/cureus-0012-00000007529-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/422adabdbca3/cureus-0012-00000007529-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/a9d2d088a6c6/cureus-0012-00000007529-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/cf04d501d945/cureus-0012-00000007529-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/bafcb459432f/cureus-0012-00000007529-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/4f495159e25c/cureus-0012-00000007529-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1d/7198093/422adabdbca3/cureus-0012-00000007529-i05.jpg

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