伊维菌素和莫昔克丁可使常见臭虫致倦库蚊的不同菌株丧失能力：一项研究。
Ivermectin and Moxidectin Can Incapacitate Different Strains of the Common Bed Bug Cimex lectularius L.: A Study.
作者信息
Sheele Johnathan M, Lesser Elizabeth, Li Xiaolin, Schlatzer Danie, Ridge Gale
机构信息
Emergency Medicine, Mayo Clinic, Jacksonville, USA.
Emergency Medicine, Case Western Reserve University, Cleveland, USA.
出版信息
Cureus. 2020 Jan 20;12(1):e6714. doi: 10.7759/cureus.6714.
Abstract
The common bed bug L. is a hematophagous ectoparasite that has recently resurged in many western industrialized nations, in part due to pesticide resistance. Using a laboratory feeding system, we found that the antiparasitic drugs ivermectin and moxidectin did not show higher incapacitation rates in pyrethroid-resistant strains of compared to a pyrethroid-susceptible strain. Additionally, we developed a high-performance liquid chromatography (HPLC) and mass spectroscopy (MS) assay to measure the concentrations of ivermectin inside and found that ivermectin persists in the insects for up to one month. HPLC/MS will be useful in understanding the pathophysiology behind the long-term morbidity observed in that consumes a sublethal dose of ivermectin.
摘要
普通臭虫Cimex lectularius是一种吸血性体外寄生虫，近来在许多西方工业化国家再度出现，部分原因是其对杀虫剂产生了抗性。通过实验室喂养系统，我们发现抗寄生虫药物伊维菌素和莫昔克丁在对拟除虫菊酯具有抗性的臭虫品系中，与对拟除虫菊酯敏感的品系相比，并未表现出更高的失能率。此外，我们开发了一种高效液相色谱（HPLC）和质谱（MS）分析法来测量臭虫体内伊维菌素的浓度，发现伊维菌素在昆虫体内可持续存在长达一个月。HPLC/MS将有助于理解在摄入亚致死剂量伊维菌素的臭虫中观察到的长期发病机制背后的病理生理学。
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