Kochar Tanureet, Shah Hamza
Internal Medicine, Charleston Area Medical Center / West Virginia University, Charleston, USA.
Gastroenterology, Charleston Area Medical Center, Charleston, USA.
Cureus. 2020 Apr 5;12(4):e7547. doi: 10.7759/cureus.7547.
Amyloidosis is characterized by extracellular deposition of the amyloid protein. It can affect multiple organ systems but it most commonly affects the heart, kidney and gastrointestinal (GI) tract. It can occur sporadically or in association with other conditions like multiple myeloma, chronic inflammatory diseases, infections etc. Its involvement of the gastrointestinal tract is rare and diffuse. It has variable manifestations in GI tract from involving the stomach to the large bowel including liver. We present a case of 55 year old Caucasian male with recent diagnosis of multiple myeloma who presented with recurrent episodes of small bowel obstruction which was later found to be caused by amyloid deposition.
淀粉样变性的特征是淀粉样蛋白在细胞外沉积。它可累及多个器官系统,但最常影响心脏、肾脏和胃肠道。它可散发性发生,或与其他疾病如多发性骨髓瘤、慢性炎症性疾病、感染等相关。其累及胃肠道的情况罕见且呈弥漫性。它在胃肠道有多种表现,从累及胃到包括肝脏在内的大肠。我们报告一例55岁的白种男性,近期诊断为多发性骨髓瘤,该患者出现反复发作的小肠梗阻,后来发现是由淀粉样蛋白沉积引起的。