Glavin G B, Brandes L J
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
Pharmacology. 1988;37(5):277-80. doi: 10.1159/000138477.
A newly synthesized para-diphenylmethane derivative, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl (DPPE), binds with high affinity to the microsomal anti-estrogen binding site (AEBS). Recent data suggest that the DPPE/AEBS binding site is closely related to a novel low-affinity, non-H1, non-H2 histamine site which may be associated with a calcium channel. We previously have shown that DPPE markedly reduces stress-induced and ethanol-induced gastric ulcers and attenuates gastric acid secretion. We now show that DPPE also profoundly reduces cysteamine-induced duodenal ulcers in rats.
一种新合成的对二苯甲烷衍生物，N，N-二乙基-2-[4-(苯甲基)苯氧基]乙胺盐酸盐（DPPE），与微粒体抗雌激素结合位点（AEBS）具有高亲和力。最近的数据表明，DPPE/AEBS结合位点与一种新的低亲和力、非H1、非H2组胺位点密切相关，该位点可能与钙通道有关。我们之前已经表明，DPPE能显著减少应激诱导和乙醇诱导的胃溃疡，并减弱胃酸分泌。我们现在表明，DPPE还能显著减轻半胱胺诱导的大鼠十二指肠溃疡。
