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Stimulation of in vivo tumor growth and phorbol ester-induced inflammation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine HCl, a potent ligand for intracellular histamine receptors.

作者信息

Brandes L J, Beecroft W A, Hogg G R

机构信息

Department of Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

出版信息

Biochem Biophys Res Commun. 1991 Sep 30;179(3):1297-304. doi: 10.1016/0006-291x(91)91714-n.

DOI:10.1016/0006-291x(91)91714-n
PMID:1930176
Abstract

We have implicated histamine as a mediator of proliferation through its binding to novel intracellular receptors (HIC), closely associated with antiestrogen binding sites (AEBS) in microsomes and nuclei. N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE), is a potent ligand for AEBS/HIC. We now demonstrate that DPPE stimulates in vivo tumor growth (DMBA-induced mammary cancer in Sprague-Dawley rats and L5178Y leukemia in DBA/2 mice) and synergizes with phorbol-12-myristate-13-acetate (PMA) to induce inflammation and mitotic activity in mouse epidermis. Thus, ligands for intracellular histamine receptors may represent a new class of tumor promoting agents; this finding lends new credence to an important role for histamine in growth.

摘要

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