Sakata T, Fukagawa K, Ookuma K, Fujimoto K, Yoshimatsu H, Yamatodani A, Wada H
Department of Internal Medicine I, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Physiol Behav. 1988;44(4-5):539-43. doi: 10.1016/0031-9384(88)90316-2.
Neuronal histamine affects physiological functions of the hypothalamus. To investigate involvement of histamine receptors in feeding, histamine antagonists were infused into the rat third cerebroventricle. All H1- but no H2-antagonists tested, induced transient feeding during the early light when concentration of hypothalamic histamine was highest. No periprandial drinking was observed. Ambulation concomitantly increased during feeding. The effect on feeding was attenuated when brain histamine was normally low during the early dark or was decreased by alpha-fluoromethylhistidine (alpha-FMH). Bilateral microinjection indicated that the ventromedial hypothalamus, but not the lateral hypothalamus or the paraventricular nucleus, was a main locus for the induction of feeding by an H1-antagonist. The effect was completely abolished when brain histamine was decreased by pretreatment with alpha-FMH. Hypothalamic neuronal histamine suppresses food intake, at least in part, through H1-receptors in the VMH, and diurnal fluctuations of food intake may mirror neuronal histamine level.
神经元组胺影响下丘脑的生理功能。为了研究组胺受体在进食中的作用，将组胺拮抗剂注入大鼠第三脑室。所有测试的H1拮抗剂但不是H2拮抗剂，在早光期下丘脑组胺浓度最高时诱导短暂进食。未观察到围餐期饮水。进食期间行走也随之增加。当在早暗期脑组胺正常较低或被α-氟甲基组氨酸（α-FMH）降低时，对进食的影响减弱。双侧微量注射表明，腹内侧下丘脑而非外侧下丘脑或室旁核是H1拮抗剂诱导进食的主要部位。当用α-FMH预处理使脑组胺降低时，该作用完全消失。下丘脑神经元组胺至少部分通过VMH中的H1受体抑制食物摄入，食物摄入的昼夜波动可能反映神经元组胺水平。
