治愈和未治愈奶牛乳腺炎病例中分离菌的抗菌药敏比较。
Comparison of antimicrobial susceptibilities of bacterial isolates between cured and uncured cases of bovine mastitis.
机构信息
Laboratory of Veterinary Public Health, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Central Veterinary Clinical Center, Chiba Prefectural Federated Agricultural Mutual Aid Association, Chiba 299-0126, Japan.
出版信息
J Vet Med Sci. 2020 Jul 10;82(7):903-907. doi: 10.1292/jvms.19-0692. Epub 2020 May 7.
To evaluate the effect of antimicrobial susceptibility on outcomes, we compared the minimum inhibitory concentrations (MICs) for Staphylococcus, Streptococcus, and the family Enterobacteriaceae from cured and uncured mastitis cases; milk shipment for uncured cases could not be resumed within 3 weeks after initial clinical examination. A higher MIC of ampicillin and a higher MIC of cefazolin for Enterobacteriaceae isolates were observed for cured rather than uncured cases with differences in ≥2 tubes. Endotoxins are generally released from Enterobacteriaceae upon antimicrobial treatment; their amounts are presumed to be greater in mastitis cases resulting from β-lactam antibiotic-susceptible rather than -resistant microbes. For staphylococcal and streptococcal isolates, the MIC and MIC of β-lactam antibiotics were similar for cured and uncured cases.
为了评估抗菌药物敏感性对结果的影响，我们比较了治愈和未治愈乳腺炎病例中金黄色葡萄球菌、链球菌和肠杆菌科的最低抑菌浓度（MIC）；对于未治愈的病例，在首次临床检查后 3 周内不能恢复牛奶运输。与未治愈的病例相比，治愈的病例中肠杆菌科分离株的氨苄西林 MIC 和头孢唑啉 MIC 更高，差异≥2 个稀释度。抗菌药物治疗时，内毒素通常从肠杆菌科释放出来；人们认为，β-内酰胺类抗生素敏感而非耐药微生物引起的乳腺炎病例中内毒素的含量更高。对于葡萄球菌和链球菌分离株，治愈和未治愈病例的β-内酰胺类抗生素 MIC 和 MIC 相似。
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