Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ; and.
Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Retina. 2021 Feb 1;41(2):402-408. doi: 10.1097/IAE.0000000000002844.
To identify the optical coherence tomography biomarkers that can collectively predict the probability of collapse or reduction of drusenoid pigment epithelium detachment (PED).
This consecutive observational case series reviewed the clinical data of 24 eyes with non-neovascular drusenoid PED. Among the study population, 17 eyes showed collapse or reduction of drusenoid PED. The mean follow-up duration was 44.8 ± 24.6 months. Optical coherence tomography-derived parameters were analyzed at baseline, at the last available visit before reduction of PED, at the first available visit after reduction of PED, and at the final visit.
The mean subfoveal choroidal thickness showed a significant decrease after PED reduction and at the most recent visit (P = 0.015). Migration of retinal pigment epithelium cells was detected in 15 (88.2%) after PED reduction; however, there was no significance in the frequency of migration of retinal pigment epithelium cells at each time point (P = 0.392). Non-neovascular subretinal fluid was detected in 7 (41.2%) before PED reduction, 2 (11.8%) after PED reduction, and 2 (11.8%) at the final visit. Interestingly, subretinal fluid appeared more frequently just before reduction of PED (P = 0.029).
We found evidence of non-neovascular subretinal fluid and choroidal thinning before reduction in PED. This finding might be useful for detection and prediction of the progression of drusenoid PED.
确定能够综合预测脂褐质样色素上皮脱离（PED）塌陷或缩小概率的光相干断层扫描生物标志物。
本连续观察性病例系列研究回顾了 24 只非新生血管性脂褐质样 PED 眼的临床资料。在研究人群中，17 只眼出现脂褐质样 PED 塌陷或缩小。平均随访时间为 44.8±24.6 个月。在 PED 缩小前、PED 缩小前最后一次可获得的就诊时、PED 缩小后第一次可获得的就诊时和最后一次就诊时，分析光学相干断层扫描衍生参数。
PED 缩小后和最近一次就诊时，中心凹下脉络膜厚度均显著降低（P=0.015）。15 只眼（88.2%）在 PED 缩小后检测到视网膜色素上皮细胞迁移，但各时间点视网膜色素上皮细胞迁移的频率无显著差异（P=0.392）。PED 缩小前、PED 缩小后和最后一次就诊时，分别有 7 只眼（41.2%）、2 只眼（11.8%）和 2 只眼（11.8%）检测到非新生血管性视网膜下积液。有趣的是，在 PED 缩小前，更频繁地观察到视网膜下积液（P=0.029）。
我们发现 PED 缩小前存在非新生血管性视网膜下积液和脉络膜变薄的证据。这一发现可能有助于检测和预测脂褐质样 PED 的进展。
