Khater Mohamed, Nasr Mohamed, Salah Samar, Khattab Fathia M
Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Egypt.
Dermatology Resident, Belbis Hospital, Egypt.
Dermatol Ther. 2020 Jul;33(4):e13532. doi: 10.1111/dth.13532. Epub 2020 May 22.
Vitiligo is a skin disorder commonly acquired. Although different therapies are used, they are refractory to therapy in many cases. Trauma has been reported to cause hyperpigmentation by the pigment incontinence, which results in the build-up of melanophages in the upper dermis after basal cell layer destruction. To detect the effectiveness of trichloroacetic acid (TCA) 70% in the treatment of nonsegmental vitiligo after skin microneedling by dermapen or intradermal injection of 5-fluorouracil.
A prospective comparative study was enrolled with 32 patients with vitiligo who were assigned to two equal groups. Each containing 16 patients; group 1 was treated by microneedling followed by TCA 70%, group 2 was treated by intradermal 5-FU injection. This was done every 2 weeks for 2 months.
According to the Physician's Global Assessment, there was no significant (P < .05) difference in the therapeutic response between the two studied groups.
Both microneedling plus TCA 70% and 5-FU intradermal injection are a simple means of treating vitiligo with cosmetically accepted repigmentation of all age groups, as well as a relatively safe alternative or additive method that can be used before (or in combination with) any of the well-known and widely approved method for stable nonsegmented vitiligo treatment.
白癜风是一种常见的后天性皮肤病。尽管使用了不同的治疗方法，但在许多情况下治疗效果不佳。据报道，创伤可通过色素失禁导致色素沉着过度，在基底细胞层破坏后，导致真皮上层黑素巨噬细胞积聚。目的是检测70%三氯乙酸（TCA）在皮肤微针或皮内注射5-氟尿嘧啶后治疗非节段性白癜风的有效性。
一项前瞻性对照研究纳入了32例白癜风患者，分为两组，每组16例。第1组采用微针治疗后再用70% TCA治疗，第2组采用皮内注射5-氟尿嘧啶治疗。每2周进行一次，共2个月。
根据医生的整体评估，两组的治疗反应无显著差异（P < 0.05）。
微针联合70% TCA和皮内注射5-氟尿嘧啶都是治疗白癜风的简单方法，所有年龄组的色素再生在美容上均可接受，也是一种相对安全的替代或附加方法，可在任何公认的、广泛应用于稳定非节段性白癜风治疗的方法之前（或联合）使用。
