Salem Maha Wafic, Adel Abd El Azim Amira, Galal Sara Ahmed
Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.
Dermatology and Venereology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
J Cosmet Dermatol. 2023 May;22(5):1521-1527. doi: 10.1111/jocd.15621. Epub 2023 Jan 31.
Vitiligo is a depigmenting disorder caused by the destruction of melanocytes by various mechanisms which affect melanocyte function and survival. Different therapeutic approaches for vitiligo include nonsurgical and surgical methods but effective therapy is still challenging. There are few studies that suggest the role of vitamin D analogs in the repigmentation process with encouraging results. To our knowledge, this is the first study to evaluate the effect of topical vitamin D (cholecalciferol) combined with microneedling in the treatment of depigmented patches of vitiligo.
Evaluate the effect of microneedling alone versus microneedling with topical vitamin D in the treatment of vitiligo.
A prospective comparative clinical trial was carried out on 25 patients with stable vitiligo; every patient had at least two patches; the first patch was treated with microneedling alone. The other patch was treated with microneedling combined with topical cholecalciferol.
Good-to-excellent response was detected in 52% of the patches treated with microneedling topical cholecalciferol, while only in 40% of the patches treated with microneedling alone. The improvement was higher in combined treatment with no significant difference between both groups.
Topical cholecalciferol is a relatively effective and safe alternative in the treatment of stable vitiligo and its combination with microneedling increases its efficacy.
白癜风是一种色素脱失性疾病，由多种影响黑素细胞功能和存活的机制导致黑素细胞破坏引起。白癜风的不同治疗方法包括非手术和手术方法，但有效的治疗仍然具有挑战性。少数研究表明维生素D类似物在色素再生过程中发挥作用，结果令人鼓舞。据我们所知，这是第一项评估外用维生素D（胆钙化醇）联合微针治疗白癜风色素脱失斑效果的研究。
评估单独微针治疗与外用维生素D联合微针治疗白癜风的效果。
对25例稳定期白癜风患者进行了一项前瞻性比较临床试验；每位患者至少有两块斑片；第一块斑片仅采用微针治疗。另一块斑片采用微针联合外用胆钙化醇治疗。
外用胆钙化醇微针治疗的斑片中，52%检测到良好至优秀的反应，而仅微针治疗的斑片中只有40%。联合治疗的改善程度更高，两组之间无显著差异。
外用胆钙化醇是治疗稳定期白癜风的一种相对有效且安全的替代方法，其与微针联合使用可提高疗效。
