Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan; Department of Critical Care Medicine (Dr. Zhang), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, P.R. China.
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
J Affect Disord. 2020 Jul 1;272:110-115. doi: 10.1016/j.jad.2020.03.128. Epub 2020 Apr 29.
The colony stimulating factor 1 receptor (CSF1R) regulates microglia/macrophage proliferation, differentiation and survival; however, the precise role of this protein in psychiatric disorders is unknown. CSF1R is also known to interact with the transcription factor PU.1 (SPI1). Here we studied whether the expressions of CSF1R and SPI1 are altered in the postmortem samples (parietal cortex, cerebellum, spleen) from patients with major psychiatric disorders.
Protein expression of CSF1R and SPI1 in the parietal cortex, cerebellum and spleen from control, major depressive disorder (MDD), schizophrenia (SZ), and bipolar disorder (BD) groups was measured.
Levels of CSF1R in the spleen, but not cerebellum and parietal cortex, from MDD and SZ groups were significantly lower than the control group. There was a positive correlation between CSF1R levels in the spleen and CSF1R levels in the parietal cortex in the all subjects from four groups. Furthermore, levels of SPI1 in the cerebellum and spleen from MDD and SZ groups were significantly higher than the control group. Levels of SPI1 in the parietal cortex were not different among the four groups. Interestingly, there was a negative correlation between CSF1R and SPI1 levels in the spleen of the all subjects from four groups. There was also a negative correlation between CSF1R and SPI1 levels in the spleen of MDD group.
The small number in each group may limit our interpretation.
Abnormalities in CSF1R and SPI1 in the brain-spleen axis might, in part, play a role in the pathophysiology of MDD.
集落刺激因子 1 受体（CSF1R）调节小胶质细胞/巨噬细胞的增殖、分化和存活；然而，该蛋白在精神疾病中的确切作用尚不清楚。CSF1R 还已知与转录因子 PU.1（SPI1）相互作用。在这里，我们研究了主要精神疾病患者死后样本（顶叶皮层、小脑、脾脏）中 CSF1R 和 SPI1 的表达是否发生改变。
测量对照组、重度抑郁症（MDD）、精神分裂症（SZ）和双相情感障碍（BD）组患者顶叶皮层、小脑和脾脏中 CSF1R 和 SPI1 的蛋白表达。
MDD 和 SZ 组的脾脏 CSF1R 水平（但小脑和顶叶皮层无）明显低于对照组。四组所有受试者的脾脏 CSF1R 水平与顶叶皮层 CSF1R 水平呈正相关。此外，MDD 和 SZ 组小脑和脾脏中的 SPI1 水平明显高于对照组。四组的顶叶皮层 SPI1 水平无差异。有趣的是，四组所有受试者的脾脏 CSF1R 和 SPI1 水平呈负相关。MDD 组的脾脏 CSF1R 和 SPI1 水平也呈负相关。
每组的数量较少可能限制我们的解释。
脑-脾轴中 CSF1R 和 SPI1 的异常可能部分参与了 MDD 的病理生理学。
