School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; MetaCognition Interest Group (MCIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Complement Ther Clin Pract. 2020 May;39:101162. doi: 10.1016/j.ctcp.2020.101162. Epub 2020 Apr 7.
and purpose: The impact of music on the human body extends beyond an emotional response. Music can bring benefits to the cardiovascular system by influencing heart rate variability (HRV), which is a well-accepted method to analyze the oscillations of the intervals between successive heartbeats and investigate the cardiovascular autonomic nervous system (ANS). This study is a systematic review to examine the effect of musical interventions on HRV.
We conducted a systematic search in PubMed, Scopus, Web of Science, and Cochrane and identified additional studies with hand searching of reference lists of relevant references.
29 original articles (24 pre-post intervention studies and five randomized controlled trials) with a total of 1368 subjects were available and eligible to be included in the systematic review. Within the whole, only three studies reveal no significant impact of music on HRV, which might be due to using a small sample size and a concise duration of music administration. Interestingly, the rest of the studies have suggested a positive impact of music on HRV with a 0.05 level of significance.
This systematic review confirms music as a stimulus acting to the cardiac ANS that increases parasympathetic activity and HRV. The effects are, however, associated with a high risk of bias. Therefore, further studies are necessary to compare the impact of individualized music therapy to passive listening and preferred soundtracks.
音乐对人体的影响不仅限于情感反应。音乐可以通过影响心率变异性（HRV）来为心血管系统带来益处，HRV 是一种分析连续心跳之间间隔波动并研究心血管自主神经系统（ANS）的公认方法。本研究是一项系统综述，旨在检查音乐干预对 HRV 的影响。
我们在 PubMed、Scopus、Web of Science 和 Cochrane 中进行了系统搜索，并通过手动搜索相关参考文献的参考文献列表来确定其他研究。
共有 29 篇原始文章（24 篇前后干预研究和 5 篇随机对照试验），共有 1368 名受试者符合纳入系统综述的标准。在整体上，只有三项研究表明音乐对 HRV 没有显著影响，这可能是由于使用了小样本量和音乐管理时间短。有趣的是，其余的研究表明音乐对 HRV 有积极的影响，具有 0.05 水平的显著性。
这项系统综述证实了音乐作为一种刺激作用于心脏 ANS，增加副交感神经活动和 HRV。然而，这些影响与高偏倚风险相关。因此，需要进一步的研究来比较个性化音乐治疗与被动聆听和首选配乐的影响。
