Handa R K, Johns E J
Department of Physiology, The Medical School, Birmingham.
Q J Exp Physiol. 1988 Nov;73(6):915-29. doi: 10.1113/expphysiol.1988.sp003226.
Brachial nerve stimulation at 3 Hz in sodium pentobarbitone-anaesthetized rats, with constant renal arterial pressure, increased systemic blood pressure, did not alter glomerular filtration rate but reduced renal blood flow, absolute and fractional sodium excretions and urine flow. In renally denervated animals, stimulation caused similar changes in blood pressure and renal haemodynamics but significantly smaller reductions in sodium and water excretions. Brachial nerve stimulation at 30 Hz caused changes in blood pressure and renal function identical to those obtained with low-frequency stimulation but these responses were not modified by renal denervation. The results show that renal nerves are necessary to promote sodium and water reabsorption in response to low- but not high-frequency stimulation of the brachial nerves in the rat.
在戊巴比妥钠麻醉、肾动脉压恒定的大鼠中，以3赫兹频率刺激臂神经，会使全身血压升高，不改变肾小球滤过率，但会降低肾血流量、钠排泄绝对值和分数以及尿流量。在去肾神经支配的动物中，刺激会引起类似的血压和肾血流动力学变化，但钠和水排泄的减少幅度明显较小。以30赫兹频率刺激臂神经引起的血压和肾功能变化与低频刺激时相同，但这些反应不受肾去神经支配的影响。结果表明，在大鼠中，肾神经对于响应臂神经的低频而非高频刺激促进钠和水的重吸收是必要的。
