躯体神经刺激对完整、迷走神经切断及颈动脉窦去神经大鼠肾脏的影响。

Effect of somatic nerve stimulation on the kidney in intact, vagotomized and carotid sinus-denervated rats.

作者信息

Davis G, Johns E J

机构信息

Department of Physiology, Medical School, Birmingham.

出版信息

J Physiol. 1991 Jan;432:573-84. doi: 10.1113/jphysiol.1991.sp018401.

DOI:10.1113/jphysiol.1991.sp018401

PMID:1886069

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1181342/

Abstract

The influence of cardiopulmonary and arterial baroreceptors on the renal nerve-dependent functional responses of the kidney to electrical stimulation of somatic afferent nerves was studied in pentobarbitone-anaesthetized rats. 2. Electrical stimulation of the left brachial nerve plexus at 3 Hz, 0.2 ms and 15 V in the intact animals increased blood pressure by 22%, and while renal perfusion pressure was maintained at pre-stimulus levels, renal blood flow and glomerular filtration rate decreased by 14 and 22% respectively. At the same time urine flow rate and absolute and fractional sodium excretion decreased by 36, 42 and 27% respectively. In animals subjected to acute renal nerve section these renal functional responses could not be elicited. 3. Following bilateral vagotomy the systemic and renal haemodynamic responses to brachial nerve stimulation were similar to the intact group. However, urine flow rate and absolute and fractional sodium excretions decreased by 50, 59 and 47% respectively, responses which were significantly greater than in the intact group. 4. In a group of rats in which the carotid sinus nerves had been sectioned, stimulation of the brachial plexus caused reductions of renal blood flow and glomerular filtration rate of the same magnitude as in the intact group; however, urine flow rate and absolute and fractional sodium excretion fell by 51, 60 and 48%, respectively, which were significantly larger than in the intact group. 5. These results demonstrate that the afferent nerve information arising from muscle joints and skin and carried via the brachial plexus caused reflex renal nerve-dependent reductions in renal haemodynamics and an antidiuresis and antinatriuresis. The cardiopulmonary and carotid sinus baroreceptors exert a tonic inhibitory action on these reflex renal responses insofar as they appeared to attenuate the antidiuretic and antinatriuretic responses to somatic afferent nerve stimulation.

摘要

在戊巴比妥麻醉的大鼠中，研究了心肺和动脉压力感受器对肾脏依赖肾神经的功能反应的影响，该反应是肾脏对躯体传入神经电刺激的反应。2. 在完整动物中，以3Hz、0.2ms和15V的频率电刺激左臂神经丛，血压升高22%，同时肾灌注压维持在刺激前水平，肾血流量和肾小球滤过率分别下降14%和22%。与此同时，尿流率以及钠排泄总量和分数排泄率分别下降36%、42%和27%。在急性切断肾神经的动物中，这些肾脏功能反应无法被诱发。3. 双侧迷走神经切断术后，对臂神经刺激的全身和肾脏血流动力学反应与完整组相似。然而，尿流率以及钠排泄总量和分数排泄率分别下降50%、59%和47%，这些反应明显大于完整组。4. 在一组切断颈窦神经的大鼠中，刺激臂丛神经导致肾血流量和肾小球滤过率的降低幅度与完整组相同；然而，尿流率以及钠排泄总量和分数排泄率分别下降51%、60%和48%，明显大于完整组。5. 这些结果表明，来自肌肉关节和皮肤并通过臂丛神经传导的传入神经信息引起了依赖肾神经的反射性肾脏血流动力学降低以及抗利尿和抗钠尿作用。心肺和颈窦压力感受器对这些反射性肾脏反应发挥了紧张性抑制作用，因为它们似乎减弱了对躯体传入神经刺激的抗利尿和抗钠尿反应。