Department of Traditional Chinese Medicine, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Front Immunol. 2024 Feb 1;15:1343316. doi: 10.3389/fimmu.2024.1343316. eCollection 2024.
Lung cancer (LC) produces some of the most malignant tumors in the world, with high morbidity and mortality. Tumor immune microenvironment (TIME), a component of the tumor microenvironment (TME), are critical in tumor development, immune escape, and drug resistance. The TIME is composed of various immune cells, immune cytokines, etc, which are important biological characteristics and determinants of tumor progression and outcomes. In this paper, we reviewed the recently published literature and discussed the potential uses of natural products in regulating TIME. We observed that a total of 37 natural compounds have been reported to exert anti-cancer effects by targeting the TIME. In different classes of natural products, terpenoids are the most frequently mentioned compounds. TAMs are one of the most investigated immune cells about therapies with natural products in TIME, with 9 natural products acting through it. 17 natural products exhibit anti-cancer properties in LC by modulating PD-1 and PD-L1 protein activity. These natural products have been extensively evaluated in animal and cellular LC models, but their clinical trials in LC patients are lacking. Based on the current review, we have revealed that the mechanisms of LC can be treated with natural products through TIME intervention, resulting in a new perspective and potential therapeutic drugs.
肺癌（LC）是世界上最恶性的肿瘤之一，具有高发病率和死亡率。肿瘤免疫微环境（TIME）是肿瘤微环境（TME）的组成部分，在肿瘤发展、免疫逃逸和耐药性方面起着关键作用。TIME 由各种免疫细胞、免疫细胞因子等组成，是肿瘤进展和结局的重要生物学特征和决定因素。本文综述了近期发表的文献，讨论了天然产物在调节 TIME 方面的潜在用途。我们观察到，共有 37 种天然化合物被报道通过靶向 TIME 发挥抗癌作用。在不同类别的天然产物中，萜类化合物是被提及最多的化合物。TAMs 是研究天然产物在 TIME 中治疗作用最广泛的免疫细胞之一，有 9 种天然产物通过它发挥作用。17 种天然产物通过调节 PD-1 和 PD-L1 蛋白活性在 LC 中表现出抗癌特性。这些天然产物已经在动物和细胞 LC 模型中进行了广泛评估，但在 LC 患者中的临床试验却缺乏。基于目前的综述，我们已经揭示了通过 TIME 干预可以用天然产物治疗 LC 的机制，为新的视角和潜在的治疗药物提供了依据。
