Yao Rongmei, Geng Zihan, Mao Xin, Bao Yanyan, Guo Shanshan, Bao Lei, Sun Jing, Gao Yingjie, Xu Yingli, Guo Bo, Meng Fengxian, Cui Xiaolan
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
College of Traditional Chinese Medicine, North China University of Sciences and Technology, Tangshan 063210, China.
Evid Based Complement Alternat Med. 2020 Apr 21;2020:3095624. doi: 10.1155/2020/3095624. eCollection 2020.
Gouty arthritis is an inflammatory joint disease closely related to hyperuricemia. It is characterized by deposition of monosodium urate crystals in the joints, resulting in an intense inflammatory process and pain. Control of hyperuricemia and anti-inflammation treatments are the main therapeutic approaches. However, the commonly used drugs for inhibiting uric acid and acute gouty arthritis have obvious gastrointestinal and renal toxicity; thus, there is an urgency to develop new alternative therapeutic drugs. An extract of (TTC), a compound drug used in traditional Chinese medicine, has been widely applied to the clinical treatment of arthritis. In this study, we investigated the therapeutic effects of TTC on gouty arthritis. In this study, an animal model of acute gouty arthritis with hyperuricemia was established using potassium oxonate and monosodium urate crystals. After treatment with TTC, the results showed obvious therapeutic effects on the rat model of acute gouty arthritis. The treatment significantly attenuated the degree of ankle swelling, inflammation, and dysfunction index, and the levels of proinflammatory cytokines. In addition, TTC has significant antihyperuricemia activity in rats with hyperuricemia induced by potassium oxonate. Histological evaluation showed that TTC relieved pathological damage in rats with acute gouty arthritis induced by monosodium urate crystals. All the groups treated with TTC showed improvement in cartilage degeneration, cell degeneration, synovial hyperplasia, and inflammatory cell invasion in the ankle joint of rats. TTC significantly alleviated swelling, inflammation, and bleeding of the renal corpuscle and convoluted tubules of rats. The results of this study suggest that TTC is capable of treating gouty arthritis and decreasing ankle injury through the control of uric acid and inflammation.
痛风性关节炎是一种与高尿酸血症密切相关的炎性关节疾病。其特征是尿酸单钠晶体在关节中沉积，导致强烈的炎症过程和疼痛。控制高尿酸血症和抗炎治疗是主要的治疗方法。然而，常用的抑制尿酸和治疗急性痛风性关节炎的药物具有明显的胃肠道和肾脏毒性；因此，迫切需要开发新的替代治疗药物。中药复方制剂（TTC）提取物已广泛应用于关节炎的临床治疗。在本研究中，我们研究了TTC对痛风性关节炎的治疗作用。在本研究中，使用氧嗪酸钾和尿酸单钠晶体建立了伴有高尿酸血症的急性痛风性关节炎动物模型。用TTC治疗后，结果显示对急性痛风性关节炎大鼠模型有明显的治疗效果。该治疗显著减轻了踝关节肿胀、炎症和功能障碍指数以及促炎细胞因子水平。此外，TTC对氧嗪酸钾诱导的高尿酸血症大鼠具有显著的抗高尿酸血症活性。组织学评估显示，TTC减轻了尿酸单钠晶体诱导的急性痛风性关节炎大鼠的病理损伤。所有用TTC治疗的组在大鼠踝关节软骨退变、细胞退变、滑膜增生和炎性细胞浸润方面均有改善。TTC显著减轻了大鼠肾小体和肾小管的肿胀、炎症和出血。本研究结果表明，TTC能够通过控制尿酸和炎症来治疗痛风性关节炎并减轻踝关节损伤。
