Institute of Molecular Medicine, Medical College of Eastern Liaoning University, Dandong, 118000, China.
Department of Pathology, Fifth People's Hospital of Shenyang City, Shenyang Tumor Hospital, Shenyang, 110023, China.
Eur Arch Otorhinolaryngol. 2020 Nov;277(11):3155-3160. doi: 10.1007/s00405-020-06023-6. Epub 2020 May 7.
MALAT1 is recognized as an oncogenic lncRNA in various malignancies. Here, the authors aim to explore the association of MALAT1 expression and prognostic implication in tongue squamous cell carcinoma (SCC).
The tongue tissues of 128 tongue SCC cases satisfying strict follow-up criteria and 28 normal cases were subjected to qRT-PCR assay for monitoring MALAT1 expression. Chi-square test was applied to explore the correlation between MALAT1 expression and clinicopathological features of tongue SCC. Kaplan-Meier analysis was used to calculate survival rates. Cox proportional hazard analysis was adopted to analyze the relationship between prognostic factors and patient survival.
The expression of MALAT1 was upregulated in tongue SCC, compared to normal tongue tissues. The expression level of MALAT1 was correlated to differentiation and stage of tongue SCC, and high MALAT1 expression was associated with low disease-free survival and overall survival rates. Moreover, advanced tongue SCC patients with high MALAT1 level had lower disease-free survival and decreased overall survival rate than patients with low MALAT1 level. These results revealed that MALAT1 overexpression can be considered as a significant prognostic factor to independently predict the disease-free survival and overall survival rate of tongue SCC.
The expression level of MALAT1 is closely related with progression of tongue SCC. Furthermore, MALAT1 can serve as an independent biomarker for prognostic evaluation of tongue SCC.
MALAT1 被认为是多种恶性肿瘤中的致癌 lncRNA。作者旨在探讨 MALAT1 表达与舌鳞状细胞癌（SCC）预后的关系。
对满足严格随访标准的 128 例舌 SCC 病例和 28 例正常病例的舌组织进行 qRT-PCR 检测 MALAT1 表达。采用卡方检验探讨 MALAT1 表达与舌 SCC 临床病理特征的相关性。Kaplan-Meier 分析计算生存率。采用Cox 比例风险分析分析预后因素与患者生存的关系。
与正常舌组织相比，MALAT1 在舌 SCC 中呈上调表达。MALAT1 的表达水平与舌 SCC 的分化和分期相关，高 MALAT1 表达与低无病生存率和总生存率相关。此外，高 MALAT1 水平的晚期舌 SCC 患者无病生存率和总生存率均低于低 MALAT1 水平的患者。这些结果表明，MALAT1 过表达可作为独立的预后因素，预测舌 SCC 的无病生存率和总生存率。
MALAT1 的表达水平与舌 SCC 的进展密切相关。此外，MALAT1 可作为舌 SCC 预后评估的独立生物标志物。
