Nagdeve Sanket Naresh, Suganthan Baviththira, Ramasamy Ramaraja P
Nano Electrochemistry Laboratory, School of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, USA.
Sensors (Basel). 2025 Feb 27;25(5):1459. doi: 10.3390/s25051459.
Oral cancer continues to cause profound suffering and is associated with high mortality rates. Early detection techniques are crucial in enhancing patient outcomes. This review paper thoroughly evaluates the significance of biomarkers and recent advancements in oral cancer detection, emphasizing cutting-edge electrochemical methods. The paper provides an epidemiological and etiological overview, outlining its clinical importance and reviewing the current state of the art in detection methods. Despite considerable progress, conventional methods exhibit limitations such as invasiveness, long wait times, and a lack of accuracy, creating a critical need for more robust technologies. This review emphasizes the significance of oral cancer biomarkers, which are considered promising cues for early detection, facilitating the development of innovative biosensing technologies. This review seeks to illuminate the recent advances in early detection and precision diagnostics, along with the usage of artificial intelligence strategies, ultimately contributing to significant progress in the battle against oral cancer.
口腔癌持续造成巨大痛苦，且死亡率很高。早期检测技术对于改善患者预后至关重要。这篇综述文章全面评估了生物标志物的重要性以及口腔癌检测的最新进展，重点介绍了前沿的电化学方法。该文章提供了流行病学和病因学概述，概述了其临床重要性，并回顾了检测方法的当前技术水平。尽管取得了相当大的进展，但传统方法仍存在局限性，如具有侵入性、等待时间长和缺乏准确性，这迫切需要更强大的技术。本综述强调了口腔癌生物标志物的重要性，它们被认为是早期检测的有前景的线索，有助于创新生物传感技术的发展。本综述旨在阐明早期检测和精准诊断的最新进展，以及人工智能策略的应用，最终为抗击口腔癌的斗争取得重大进展做出贡献。
