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1
May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications?正在服用 5α-还原酶抑制剂的患者是否有更高的 COVID-19 并发症风险？
Med Hypotheses. 2020 Jul;140:109751. doi: 10.1016/j.mehy.2020.109751. Epub 2020 Apr 22.
2
5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety.5α还原酶抑制剂在雄激素性脱发中的应用：范式转变、当前概念、疗效比较及安全性
Dermatol Ther. 2020 May;33(3):e13379. doi: 10.1111/dth.13379. Epub 2020 Apr 24.
3
What does androgenetic alopecia have to do with COVID-19? An insight into a potential new therapy.雄激素性脱发与新冠病毒有何关联？对一种潜在新疗法的深入探讨。
Dermatol Ther. 2020 Jul;33(4):e13365. doi: 10.1111/dth.13365. Epub 2020 Apr 8.
4
Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2.预测血管紧张素转化酶 2（ACE2）作为 SARS-CoV-2 受体的利用能力。
Microbes Infect. 2020 May-Jun;22(4-5):221-225. doi: 10.1016/j.micinf.2020.03.003. Epub 2020 Mar 19.
5
The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases.5α-还原酶同工酶家族：基础生物学及其在人类疾病中作用的综述
Adv Urol. 2012;2012:530121. doi: 10.1155/2012/530121. Epub 2011 Dec 25.
6
Gene expression profile of androgen modulated genes in the murine fetal developing lung.雄激素调控基因在胎鼠肺发育中的基因表达谱。
Reprod Biol Endocrinol. 2010 Jan 8;8:2. doi: 10.1186/1477-7827-8-2.
7
Androgen receptor and androgen-dependent gene expression in lung.肺中的雄激素受体和雄激素依赖性基因表达。
Mol Cell Endocrinol. 2010 Apr 12;317(1-2):14-24. doi: 10.1016/j.mce.2009.12.022. Epub 2009 Dec 24.
8
Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by transforming growth factor beta 1 through the Smad pathway.肺泡II型上皮细胞向I型细胞的转分化涉及转化生长因子β1通过Smad信号通路的自分泌信号传导。
J Biol Chem. 2007 Feb 9;282(6):3968-76. doi: 10.1074/jbc.M609060200. Epub 2006 Dec 11.
9
Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation.人肺成纤维细胞中的雄激素失活：2型17β-羟类固醇脱氢酶和5α-还原酶活性水平的变化与雄激素失活相符。
J Clin Endocrinol Metab. 2002 Aug;87(8):3883-92. doi: 10.1210/jcem.87.8.8764.
10
Alveolar type II cell-fibroblast interactions, synthesis and secretion of surfactant and type I collagen.肺泡II型细胞与成纤维细胞的相互作用、表面活性剂和I型胶原蛋白的合成与分泌。
J Cell Sci. 1993 Jun;105 ( Pt 2):423-32. doi: 10.1242/jcs.105.2.423.

Effects of 5-alpha reductase inhibitors on lung function: A reason for discontinuation during COVID-19 pandemic?

作者信息

Kroumpouzos George

机构信息

Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Department of Dermatology, Medical School of Jundiaí, São Paulo, Brazil.

出版信息

Dermatol Ther. 2020 Jul;33(4):e13535. doi: 10.1111/dth.13535. Epub 2020 May 20.

DOI:10.1111/dth.13535
PMID:32383237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7262018/
Abstract
摘要