Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
Department of Public Health, Graduate School, Hanyang University, Seoul, Korea.
J Korean Med Sci. 2020 May 11;35(18):e121. doi: 10.3346/jkms.2020.35.e121.
This study aimed to identify the incidence rate of episodes diagnosed with influenza and the effects of age-period-cohort (APC) in Koreans.
The 2009-2018 National Health Insurance Research Database was used for analysis. All time-related claims connected relatively short window period in 100 days. The case definition was defined by all codes diagnosed with J09, J10, and J11. Calculation of the incidence rate and APC analysis adjusted income levels by insurance type, metropolitan city was performed to identify the characteristics of episodes diagnosed with influenza.
Incidence rate by age and cohort gradually increased since 2014. The incidence rate of males aged 0-4 years was 171.02 and that of females was 173.31 in 2015-2016 season. In males, 29.19 in 1963 cohort and 243.79 in 2013 cohort were confirmed as high incidence rates in 2017-2018 season. In the females, a high incidence was confirmed in 1953-1967 cohort and 1978-1987 cohort, and the incidence was 251.38 in 2013-2017 cohort. APC effects showed a high relative risk in the infants, the pandemic influenza season in 2010 (1/7/2009 to 30/6/2010) and the adults of 1978-1987 cohort.
Since 2014, influenza outbreaks have been increasing every year. The start year of free vaccination decreased the incidence in infants and adults over 65 years of age but the incidence increased from the following year. Because influenza can be primarily prevented by vaccination, reinforcement of vaccination in infants may reduce the disease burden in their parents, and also the risk of infection caused by family transmission. A new vaccination strategy is needed to reduce the incidence and burden of diseases caused by influenza infection.
本研究旨在确定韩国流感确诊病例的发病率以及年龄-时期-队列（APC）的影响。
本研究使用 2009-2018 年国家健康保险研究数据库进行分析。所有与相对较短的 100 天窗口期相关的时间相关索赔都与该数据库相关联。病例定义由所有诊断为 J09、J10 和 J11 的代码定义。根据保险类型和大都市调整收入水平，计算发病率和 APC 分析，以确定流感确诊病例的特征。
自 2014 年以来，按年龄和队列计算的发病率逐渐增加。2015-2016 季节，男性 0-4 岁年龄组的发病率为 171.02，女性为 173.31。在男性中，1963 队列的 29.19 和 2013 队列的 243.79 被确定为 2017-2018 季节的高发病率。在女性中，1953-1967 队列和 1978-1987 队列的发病率较高，2013-2017 队列的发病率为 251.38。APC 效应显示，婴儿、2010 年大流行流感季节（2009 年 7 月 1 日至 6 月 30 日）和 1978-1987 队列的成年人的相对风险较高。
自 2014 年以来，流感疫情每年都在增加。免费接种的开始年份降低了婴儿和 65 岁以上成年人的发病率，但次年发病率上升。由于流感主要可以通过疫苗接种预防，加强婴儿疫苗接种可能会降低其父母的疾病负担，也会降低家庭传播引起的感染风险。需要新的疫苗接种策略来降低流感感染引起的发病率和疾病负担。
