School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Birck Nanotechnology Center, Center for Implantable Device, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
ACS Appl Mater Interfaces. 2020 Jun 3;12(22):24564-24574. doi: 10.1021/acsami.0c02826. Epub 2020 May 20.
Glutamate, one of the main neurotransmitters in the brain, plays a critical role in communication between neurons, neuronal development, and various neurological disorders. Extracellular measurement of neurotransmitters such as glutamate in the brain is important for understanding these processes and developing a new generation of brain-machine interfaces. Here, we demonstrate the use of a perovskite nickelate-Nafion heterostructure as a promising glutamate sensor with a low detection limit of 16 nM and a response time of 1.2 s amperometric sensing. We have designed and successfully tested novel perovskite nickelate-Nafion electrodes for recording of glutamate release in electrically stimulated brain slices and from the primary visual cortex (V1) of awake mice exposed to visual stimuli. These results demonstrate the potential of perovskite nickelates as sensing media for brain-machine interfaces.
谷氨酸是大脑中的主要神经递质之一，在神经元之间的通讯、神经元发育和各种神经紊乱中起着关键作用。测量大脑中神经递质如谷氨酸的细胞外浓度对于理解这些过程和开发新一代脑机接口非常重要。在这里，我们展示了使用钙钛矿镍酸盐-纳滤异质结构作为一种有前途的谷氨酸传感器，具有低检测限 16 nM 和 1.2 s 的响应时间安培感应。我们设计并成功测试了新型钙钛矿镍酸盐-纳滤电极，用于记录电刺激脑片和在暴露于视觉刺激的清醒小鼠的初级视觉皮层（V1）中释放的谷氨酸。这些结果表明钙钛矿镍酸盐作为脑机接口传感介质的潜力。
