Mansoura University Egypt, Mansoura, Egypt.
Adv Respir Med. 2020;88(2):129-133. doi: 10.5603/ARM.2020.0087.
Inducible laryngeal obstruction (ILO) is an important cause of a variety of respiratory symptoms and can mimic bronchial asthma (BA). This study was planned to measure the prevalence of ILO among patients diagnosed with BA and to detect its effect on BA control and severity.
Patients aged 18 years or older who were previously diagnosed with BA were enrolled. Laryngeal obstruction was induced using the patient's specific trigger (e.g. exercise). Visualization of vocal folds was accomplished using a 70-degree rigid laryngoscope (Karl Storz). A visual grade score was utilized to determine the severity of laryngeal obstruction.
Results showed that 38.3% (n = 46) of the patients had ILO with the majority being classified as grade 2 (80.4%) (n = 37). The most common subtype was glottic ILO (63%). Bronchial asthma duration, level of control, and severity were not associated with ILO (P values: 0.2, 0.3 and 0.8 respectively).
Asthma and ILO commonly co-exist. An accurate classification of patients is very important and must be considered in order to determine whether the symptoms are directly related to ILO or whether they are caused by BA. Ceasing inappropriate treatment may be necessary. Objective diagnostic modalities of ILO are essential.
可诱导性喉阻塞（ILO）是多种呼吸症状的重要原因，并可模拟支气管哮喘（BA）。本研究旨在测量诊断为 BA 的患者中 ILO 的患病率，并检测其对 BA 控制和严重程度的影响。
招募年龄在 18 岁或以上且先前被诊断为 BA 的患者。使用患者的特定触发因素（例如运动）诱导喉阻塞。使用 70 度刚性喉镜（Karl Storz）观察声带。使用视觉分级评分来确定喉阻塞的严重程度。
结果表明，38.3%（n = 46）的患者存在 ILO，其中大多数为 2 级（80.4%）（n = 37）。最常见的亚型是声门型 ILO（63%）。支气管哮喘持续时间、控制水平和严重程度与 ILO 无关（P 值分别为 0.2、0.3 和 0.8）。
哮喘和 ILO 通常同时存在。准确分类患者非常重要，必须考虑这些症状是否与 ILO 直接相关，还是由 BA 引起的。可能需要停止不适当的治疗。ILO 的客观诊断方法必不可少。
