Fenner D, Hofmann V
Abteilung für Onkologie, Universitätsspital, Zürich.
Schweiz Med Wochenschr. 1988 Feb 4;119(5):156-9.
A retrospective analysis of 80 women with breast cancer operated on with curative intent showed that metastases developed within 8 years. The value of laboratory tests and radiological surveys for the early detection of metastases is considered. In fewer than 50% of the patients was the finding of a single abnormal laboratory result associated with tumor recurrence. However, when several findings were abnormal concomitantly this suggested tumor dissemination in about 90% of women. In 80% of the patients clinical symptoms were present at the time of tumor recurrence. In only 20% of the patients were metastases clinically silent. Since metastatic breast cancer cannot be cured by present treatment modalities, the relevance of detecting early recurrence is limited.
对80例接受根治性手术的乳腺癌女性患者进行的回顾性分析表明，转移在8年内发生。研究了实验室检查和影像学检查对早期发现转移的价值。不到50%的患者单个实验室检查结果异常与肿瘤复发相关。然而，当多个检查结果同时异常时，这提示约90%的女性发生了肿瘤播散。80%的患者在肿瘤复发时有临床症状。只有20%的患者转移在临床上无表现。由于目前的治疗方式无法治愈转移性乳腺癌，早期复发检测的相关性有限。
