Wang Xue, Jiang Yunfeng, Xiong Jun, Yuan Ting, Yang Jun, Zhou Xiaohong, Liao Kai, Xu Lingling
Jiangxi University of Traditional Chinese Medicine.
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China.
Medicine (Baltimore). 2020 May;99(19):e19974. doi: 10.1097/MD.0000000000019974.
Knee osteoarthritis (KOA) is a significant health issue because it causes pain and functional limitation. Many studies have reported that moxibustion, a treatment in traditional Chinese medicine, is effective in treating KOA. The aim of this overview is to synthesize and assess the reliability of evidence generated from these systematic reviews of the effectiveness of moxibusition for KOA.
This is a protocol for a systematic overview of reviews. We will search 7 databases: PubMed, Embase, Cochrane Library, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure, WangFang Database, Chinese Scientific Journal Database from their inception to April 2020. We will consider systematic reviews and meta-analysis of randomized controlled trials evaluating the effectiveness of moxibustion for KOA. Independent reviewers will sift, perform data extraction in duplicate, and assess the quality of the reviews using the Change MeaSurement Tool to Assess Systematic Reviews-2 to Assessment of Multiple Systematic Reviews-2 and the Preferred Reporting Item for Systematic Review and Meta-Analysis statement. The outcomes of interest include: quality of life, knee function, and pain relief outcomes prioritized in the individual reviews. The evidence will be synthesized where appropriate by patient subgroups, intervention type, context, and outcome. Revman 5.3 software will be used to conduct meta-analysis and calculate the risk ratio for dichotomous data. Weighted mean difference or standard mean difference will be calculated for continuous data. The quality of evidence was assessed according to Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considering the methodological quality of the randomized controlled trials and meta-analysis.
The results of this study will be published in a peer-reviewed journal.
We expect to compile evidence from multiple systematic reviews of symptomatic improvement in patients with KOA in an accessible and useful document.
CRD42019141029 in PROSPERO 2019.
膝关节骨关节炎（KOA）是一个重大的健康问题，因为它会导致疼痛和功能受限。许多研究报告称，中医治疗方法艾灸对治疗KOA有效。本综述的目的是综合并评估这些关于艾灸治疗KOA有效性的系统评价所产生证据的可靠性。
这是一项系统评价综述的方案。我们将检索7个数据库：PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库、中国知网、万方数据库、维普数据库，检索时间从建库至2020年4月。我们将纳入评估艾灸治疗KOA有效性的随机对照试验的系统评价和荟萃分析。独立评审员将进行筛选、重复数据提取，并使用“系统评价的测量工具变化评估-2”到“多个系统评价评估-2”以及系统评价和荟萃分析的首选报告项目声明来评估综述的质量。感兴趣的结局包括：个体综述中优先考虑的生活质量、膝关节功能和疼痛缓解结局。将根据患者亚组、干预类型、背景和结局在适当情况下综合证据。将使用Revman 5.3软件进行荟萃分析，并计算二分数据的风险比。对于连续数据，将计算加权平均差或标准化平均差。根据推荐分级、评估、制定和评价（GRADE）评估证据质量，同时考虑随机对照试验和荟萃分析的方法学质量。
本研究结果将发表在同行评审期刊上。
我们期望在一份易于获取且有用的文件中汇编来自多个关于KOA患者症状改善的系统评价的证据。
PROSPERO 2019中的CRD42019141029
