雷火灸治疗膝骨关节炎患者的疗效和安全性：系统评价和荟萃分析方案。
Efficacy and safety of thunder-fire moxibustion for patients with knee osteoarthritis: A protocol for systematic review and meta-analysis.
机构信息
The Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning.
Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
出版信息
Medicine (Baltimore). 2021 Apr 9;100(14):e25384. doi: 10.1097/MD.0000000000025384.
BACKGROUND
Knee osteoarthritis (KOA) is a major public health issue because it causes pain and functional limitation in patients. Many studies have reported that moxibustion, a treatment in traditional Chinese medicine, is effective in treating KOA. The aim of this protocol is to develop a standard in advance for synthesize and assess the efficacy and safety of thunder-fire moxibustion for KOA from these randomized controlled trial.
METHODS
The 2 commentators will screen 7 databases (PubMed, EMBASE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database) for randomized controlled trials that can be included from the time the database is built up until publication in December 2020. The original study that randomized control trials of thunder-fire moxibustion for patients with KOA will be selected and is not limited by country or language. In addition, researches in progress, the reference lists, and the citation lists of identified publications will be retrieved similarly. Study selection, data extraction, and assessment of the quality will be performed independently by 2 reviewers who have been trained before data extraction. A meta-analysis will be conduct if the quantity and quality of the original studies included are satisfactory; otherwise, a descriptive analysis will be conducted. Review Manager 5.4 software (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) will be using for data synthesis and assessment the risk of bias according to Cochrane Handbook.
RESULT
This study will provide a comprehensive review of current evidence for the treatment of thunder-fire moxibustion on KOA.
CONCLUSION
The conclusion of this study will provide a judging basis that whether the treatment of KOA with thunder-fire moxibustion is effective.
REGISTRATION NUMBER
INPLASY2020100012.
背景
膝骨关节炎（KOA）是一个主要的公共卫生问题，因为它会给患者带来疼痛和功能受限。许多研究报告称，艾灸作为一种中医治疗方法，对治疗 KOA 有效。本方案旨在为从这些随机对照试验中综合评估雷火灸治疗 KOA 的疗效和安全性制定一个标准。
方法
两名评论员将筛选 7 个数据库（PubMed、EMBASE、Cochrane 图书馆、中国知网、中国维普资讯、万方数据库和中国生物医学文献数据库），以筛选出从数据库建立到 2020 年 12 月发表的包含随机对照试验的研究。将选择对 KOA 患者进行雷火灸随机对照试验的原始研究，且不受国家或语言限制。此外，将类似地检索正在进行的研究、已确定出版物的参考文献列表和引文列表。研究选择、数据提取和质量评估将由两名经过培训的评论员独立进行。如果纳入的原始研究的数量和质量令人满意，将进行荟萃分析；否则，将进行描述性分析。Review Manager 5.4 软件（北欧 Cochrane 中心，The Cochrane Collaboration，丹麦哥本哈根）将用于根据 Cochrane 手册进行数据合成和评估偏倚风险。
结果
本研究将对雷火灸治疗 KOA 的现有证据进行全面回顾。
结论
本研究的结论将为雷火灸治疗 KOA 的有效性提供判断依据。
注册号
INPLASY2020100012。
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