组氨酸和四磷酸鸟苷对组氨酰 - tRNA - 三磷酸腺苷磷酸核糖基转移酶复合物形成的抑制作用。
Inhibition of histidyl-tRNA-adenosine triphosphate phosphoribosyltransferase complex formation by histidine and by guanosine tetraphosphate.
作者信息
Kleeman J E, Parsons S M
出版信息
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1535-7. doi: 10.1073/pnas.74.4.1535.
Abstract
Formation of the complex between the first enzyme of histidine biosynthesis from Salmonella typhimurium, ATP phosphoribosyltransferase [1-(5'-phosphoribosyl)-ATP: pyrophosphate phosphoribosyltransferase; EC 2.4.2.17], and histidyl-tRNA is shown to be inhibited by L-histidine and by guanosine-5'-diphosphate-3'-diphosphate in the presence of histidine. Higher histodine levels make guanosine tetraphosphate a more effective inhibitor. Relatively high concentrations of guanosine-5'-triphosphate also inhibit complex formation, but this inhibition is not enhanced by histidine. The possible implications of these observations with respect to the gene regulatory activity of this enzyme are discussed.
摘要
鼠伤寒沙门氏菌组氨酸生物合成的第一种酶，即ATP磷酸核糖基转移酶[1-(5'-磷酸核糖基)-ATP：焦磷酸磷酸核糖基转移酶；EC 2.4.2.17]与组氨酰-tRNA之间复合物的形成，在组氨酸存在的情况下被L-组氨酸和鸟苷-5'-二磷酸-3'-二磷酸所抑制。较高的组氨酸水平使鸟苷四磷酸成为更有效的抑制剂。相对高浓度的鸟苷-5'-三磷酸也抑制复合物的形成，但这种抑制作用不会因组氨酸而增强。文中讨论了这些观察结果对该酶基因调控活性的可能影响。
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Inhibition of histidyl-tRNA-adenosine triphosphate phosphoribosyltransferase complex formation by histidine and by guanosine tetraphosphate.组氨酸和四磷酸鸟苷对组氨酰 - tRNA - 三磷酸腺苷磷酸核糖基转移酶复合物形成的抑制作用。
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1535-7. doi: 10.1073/pnas.74.4.1535.
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Unusual CCA-stem structure of E. coli B tRNAH(His)(1).大肠杆菌B tRNAH(His)(1)的异常CCA-茎结构。
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Regulation of the expression of the histidine operon in Salmonella typhimurium.鼠伤寒沙门氏菌中组氨酸操纵子表达的调控
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Regulation of histidine biosynthesis in Salmonella typhimurium.鼠伤寒沙门氏菌中组氨酸生物合成的调控。
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Histidine regulation in Salmonella typhimurium. XI. The percentage of transfer RNA His charged in vivo and its relation to the repression of the histidine operon.鼠伤寒沙门氏菌中的组氨酸调节。十一、体内携带组氨酸的转运RNA的百分比及其与组氨酸操纵子阻遏的关系。
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