Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Eur Heart J Cardiovasc Imaging. 2021 Jan 1;22(1):67-74. doi: 10.1093/ehjci/jeaa110.
Prominent left ventricular trabeculations is a phenotypic trait observed in cardiovascular diseases. In the general population, the extent of left ventricular trabeculations is highly variable, yet it is unknown whether increased trabeculation is associated with adverse outcome.
Left ventricular trabeculated mass (g/m2) was measured with contrast-enhanced cardiac computed tomography in 10 097 individuals from the Copenhagen General Population Study. The primary endpoint was a composite of major adverse cardiovascular events and defined as death, heart failure, myocardial infarction, or stroke. The secondary endpoints were the individual components of the primary endpoint. Cox regression models were adjusted for clinical parameters, medical history, electrocardiographic parameters, and cardiac chamber sizes. The mean trabeculated mass was 19.1 g/m2 (standard deviation 4.9 g/m2). During a median follow-up of 4.0 years (interquartile range 1.5-6.7), 710 major adverse cardiovascular events occurred in 619 individuals. Individuals with a left ventricular trabeculated mass in the highest quartile had a hazard ratio for major adverse cardiovascular events of 1.64 [95% confidence interval (CI) 1.30-2.08; P < 0.001] compared to those in the lowest quartile. Corresponding hazard ratios were 2.08 (95% CI 1.38-3.14; P < 0.001) for death, 2.63 (95% CI 1.61-4.31; P < 0.001) for heart failure, 1.08 (95% CI 0.56-2.08; P = 0.82) for myocardial infarction, and 1.07 (95% CI 0.72-1.57; P = 0.74) for stroke.
Increased left ventricular trabeculation is independently associated with an increased rate of major adverse cardiovascular events in the general population.
左心室小梁化是心血管疾病中的一种表型特征。在普通人群中，左心室小梁化的程度差异很大，但目前尚不清楚小梁化程度增加是否与不良预后相关。
在哥本哈根普通人群研究中，对 10097 名个体进行了对比增强心脏计算机断层扫描测量左心室小梁化质量（g/m2）。主要终点是主要不良心血管事件的复合终点，定义为死亡、心力衰竭、心肌梗死或中风。次要终点是主要终点的各个组成部分。Cox 回归模型调整了临床参数、病史、心电图参数和心腔大小。平均小梁化质量为 19.1g/m2（标准差 4.9g/m2）。在中位数为 4.0 年（四分位间距 1.5-6.7）的随访期间，619 名个体中有 710 名发生主要不良心血管事件。左心室小梁化质量最高四分位的个体发生主要不良心血管事件的风险比为 1.64（95%置信区间 1.30-2.08；P<0.001），而最低四分位的个体为 1.00。相应的风险比为死亡 2.08（95%置信区间 1.38-3.14；P<0.001）、心力衰竭 2.63（95%置信区间 1.61-4.31；P<0.001）、心肌梗死 1.08（95%置信区间 0.56-2.08；P=0.82）和中风 1.07（95%置信区间 0.72-1.57；P=0.74）。
在普通人群中，左心室小梁化程度增加与主要不良心血管事件发生率增加独立相关。
