Shibuya A, Ninomiya H, Nakazawa M, Nagasawa T, Yoda Y, Abe T
Division of Hematology, University of Tsukuba, Ibaraki, Japan.
Thromb Haemost. 1988 Dec 22;60(3):495-7.
Three patients with familial antithrombin III (ATIII) deficiency, who also have histories of thromboembolism, were treated with oxymetholone in combination with warfarin. Thrombolysis was observed in one patient with acute thrombosis of inferior vena cava during the oxymetholone and warfarin therapy. No further thromboembolic episodes occurred in these patients after initiation of warfarin with or without oxymetholone. The levels of plasma ATIII, alpha 1-antitrypsin, plasminogen and Cl-inactivator were significantly increased in all patients after the introduction of oxymetholone therapy. This suggests that oxymetholone augments anticoagulant and fibinolytic activity. Hence we consider that oxymetholone in combination with warfarin may be possible thrombolytic therapy in patients with familial ATIII deficiency.
三名患有家族性抗凝血酶III（ATIII）缺乏症且有血栓栓塞病史的患者接受了羟甲烯龙与华法林联合治疗。在羟甲烯龙和华法林治疗期间，一名患有下腔静脉急性血栓形成的患者出现了溶栓现象。在开始使用华法林（无论是否联合羟甲烯龙）后，这些患者未再发生血栓栓塞事件。在引入羟甲烯龙治疗后，所有患者的血浆ATIII、α1-抗胰蛋白酶、纤溶酶原和C1-灭活剂水平均显著升高。这表明羟甲烯龙可增强抗凝和纤溶活性。因此，我们认为羟甲烯龙与华法林联合使用可能是家族性ATIII缺乏症患者的一种溶栓治疗方法。
