人源多能干细胞来源的小胶质细胞高保真建模
High-Fidelity Modeling of Human Microglia with Pluripotent Stem Cells.
机构信息
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Graduate Program in Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
出版信息
Cell Stem Cell. 2020 May 7;26(5):629-631. doi: 10.1016/j.stem.2020.04.004.
Abstract
Gosselin et al. (2017) reported that a tissue-environment-dependent transcriptional network specifies human microglia identity and that in vitro environments drastically alter the human microglia transcriptome. Recent 3-dimensional culture and human-mouse chimeric brain modeling systems developed using human pluripotent stem cells help us understand the complex properties of human microglia.
摘要
戈斯林等人（2017 年）报道称，组织-环境依赖的转录网络决定了人类小胶质细胞的身份，体外环境极大地改变了人类小胶质细胞的转录组。最近使用人类多能干细胞开发的 3 维培养和人-鼠嵌合脑建模系统有助于我们理解人类小胶质细胞的复杂特性。
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