Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Graduate Program in Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Cell Stem Cell. 2020 May 7;26(5):629-631. doi: 10.1016/j.stem.2020.04.004.
Gosselin et al. (2017) reported that a tissue-environment-dependent transcriptional network specifies human microglia identity and that in vitro environments drastically alter the human microglia transcriptome. Recent 3-dimensional culture and human-mouse chimeric brain modeling systems developed using human pluripotent stem cells help us understand the complex properties of human microglia.
戈斯林等人（2017 年）报道称，组织-环境依赖的转录网络决定了人类小胶质细胞的身份，体外环境极大地改变了人类小胶质细胞的转录组。最近使用人类多能干细胞开发的 3 维培养和人-鼠嵌合脑建模系统有助于我们理解人类小胶质细胞的复杂特性。
