人鼠嵌合脑模型的兴起。
Rise of the human-mouse chimeric brain models.
作者信息
Jiang Peng, Alam Mahabub Maraj
机构信息
Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ, 08854, USA.
出版信息
Cell Regen. 2022 Sep 3;11(1):32. doi: 10.1186/s13619-022-00135-6.
Abstract
Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders.
摘要
人鼠嵌合体为在体内研究人类细胞的病理生理学提供了优势。通过将人类胎儿组织或多能干细胞衍生的祖细胞移植到新生小鼠大脑中，已创建了嵌合小鼠大脑。这为理解人类大脑发育和神经疾病提供了新的机会。
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