黄酮类化合物的摄入及其与心房颤动的关系。

Flavonoid intake and its association with atrial fibrillation.

机构信息

School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia; Institute for Global Food Security, Queen's University Belfast, Northern Ireland, UK.

School of Population and Global Health, University of Western Australia, Australia.

出版信息

Clin Nutr. 2020 Dec;39(12):3821-3828. doi: 10.1016/j.clnu.2020.04.025. Epub 2020 Apr 23.

DOI:10.1016/j.clnu.2020.04.025

PMID:32386860

Abstract

BACKGROUND & AIMS: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.

METHODS

Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.

RESULTS

During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [<20 g/d: 0.97 (0.89, 1.07)].

CONCLUSION

Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF.

摘要

背景与目的

通过行为和饮食改变进行房颤（AF）的一级预防是一项至关重要但尚未满足的需求。类黄酮是具有潜在心血管健康益处的生物活性膳食化合物。我们的目的是研究类黄酮摄入量与临床明显的 AF 之间的关联。

方法

我们对丹麦饮食、癌症与健康研究中的 55613 名无 AF 参与者（1993 年至 1997 年间招募）的基线数据进行了分析，这些数据与丹麦全国登记处进行了交叉链接。使用 Phenol-Explorer 数据库从经过验证的食物频率问卷中计算总类黄酮和类黄酮亚类的摄入量。使用基于 Cox 比例风险模型的限制性立方样条，检查类黄酮摄入量与新发 AF（首次住院或门诊就诊）之间的关联。

结果

在中位数[IQR]为 21 [18-22]年的随访期间，有 7291 名参与者被诊断为 AF。总类黄酮摄入量与整个队列中 AF 的发病风险无统计学显著相关性。然而，与最低五分位数相比，每天摄入 1000 毫克的总类黄酮与吸烟者发生 AF 的风险较低[0.86（0.77，0.96）]，但在不吸烟者中则没有[0.96（0.88，1.06）]，在高酒精消费者中发生 AF 的风险较低[>20 g/d：0.84（0.75，0.95）]，但在低至中度酒精消费者中则没有[<20 g/d：0.97（0.89，1.07）]。