Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
J Nutr. 2024 Sep;154(9):2827-2833. doi: 10.1016/j.tjnut.2024.07.013. Epub 2024 Jul 16.
Omega-3 fatty acids derived from seafood acids may influence cardiac arrhythmogenesis, whereas the role of the major plant-derived omega-3 fatty acid, alpha-linolenic acid (ALA), on atrial fibrillation (AF) is largely unknown.
We aimed to investigate the association between ALA intake and risk of incident AF overall and in subjects with a low intake of marine omega-3 fatty acids.
We followed a total of 54,260 middle-aged men and women enrolled into the Danish Diet, Cancer, and Health cohort for development of AF using nationwide registries. Intake of ALA was assessed using a validated food frequency questionnaire and modeled as a restricted cubic spline. Statistical analyses were conducted using Cox proportional hazards regression.
We identified a total of 4902 incident AF events during a median of 16.9 y of follow-up. In multivariable analyses, we observed indications of a statistically nonsignificant inverse association between ALA intake and risk of AF up to an ALA intake of 2.5 g/d, whereas no appreciable association was found for higher intakes of ALA. A statistically significant dose-dependent negative association was found between ALA intake and risk of AF in individuals consuming < 250 mg marine omega-3 fatty acids daily, whereas no association was found in those with a higher intake of marine omega-3 fatty acids.
Intake of ALA was associated with a lower risk of AF in individuals consuming a low intake of marine omega-3 fatty acids. This finding is novel and warrants further investigation.
来自海鲜的 omega-3 脂肪酸可能会影响心脏心律失常的发生，而主要来源于植物的 omega-3 脂肪酸，α-亚麻酸（ALA），对心房颤动（AF）的作用在很大程度上尚不清楚。
我们旨在研究 ALA 摄入量与总体和海洋 omega-3 脂肪酸摄入量低的个体发生 AF 的风险之间的关联。
我们对总共 54260 名中年男女进行了丹麦饮食、癌症和健康队列的研究，使用全国性登记处来研究 AF 的发展。使用验证后的食物频率问卷评估 ALA 的摄入量，并采用限制性立方样条进行建模。使用 Cox 比例风险回归进行统计分析。
在中位随访 16.9 年期间，我们共发现了 4902 例新发 AF 事件。在多变量分析中，我们观察到 ALA 摄入量与 AF 风险之间存在统计学上无显著意义的负相关，直至 ALA 摄入量达到 2.5g/d，而对于更高的 ALA 摄入量则没有明显的相关性。在每日摄入<250mg 海洋 omega-3 脂肪酸的个体中，ALA 摄入量与 AF 风险之间存在统计学显著的剂量依赖性负相关，而在摄入更高海洋 omega-3 脂肪酸的个体中则没有这种相关性。
在摄入海洋 omega-3 脂肪酸较低的个体中，ALA 摄入量与 AF 风险降低相关。这一发现是新颖的，值得进一步研究。
