Zhao Junnan, Lan Xu, Liu Yue, Liu Yanfei, Xian Yanfang, Lin Zhixiu, Xu Fengqin
Institute of Geriatric Medicine, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
Cardiovascular Diseases Center, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
Ann Palliat Med. 2020 May;9(3):1230-1248. doi: 10.21037/apm.2020.04.09. Epub 2020 Apr 28.
The aging of the population has become a global health problem. It is an important risk factor for major diseases such as cardiovascular disease, Alzheimer's disease, Parkinson's disease, and cancer. Presently, there is no definite and effective anti-aging treatment. Chinese herbal medicine has a long history of application and is often used for aging-related diseases in China. A large number of clinical and preclinical studies on the anti-aging effect of Chinese herbal medicine has been performed. Through literature research, we reviewed the anti-aging clinical research of Chinese herbal medicine and preclinical research of Chinese herbal medicine monomers, components, extracts, and compounds, and their mechanisms. Results from preclinical studies have shown that Chinese herbal medicines have beneficial anti-aging effects. The mechanism mainly includes anti-oxidative stress, anti-inflammatory, neuroprotection, apoptosis and mitochondrial function regulation, etc. However, more detailed high-quality clinical trials are required for future investigation of the anti-aging effects of Chinese herbal medicines.
人口老龄化已成为一个全球性的健康问题。它是心血管疾病、阿尔茨海默病、帕金森病和癌症等重大疾病的重要风险因素。目前，尚无明确有效的抗衰老治疗方法。中药有着悠久的应用历史，在中国常被用于治疗与衰老相关的疾病。已经开展了大量关于中药抗衰老作用的临床和临床前研究。通过文献研究，我们综述了中药抗衰老的临床研究以及中药单体、成分、提取物和化合物的临床前研究及其作用机制。临床前研究结果表明，中药具有有益的抗衰老作用。其机制主要包括抗氧化应激、抗炎、神经保护、细胞凋亡和线粒体功能调节等。然而，未来对中药抗衰老作用的研究还需要更详细的高质量临床试验。
