Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Department of Blood Transfusion, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region, China.
Int J Biol Markers. 2020 Jun;35(2):66-73. doi: 10.1177/1724600820915916. Epub 2020 May 11.
Albumin to fibrinogen ratio (AFR) play a crucial role in the progression and prognosis of many malignant tumors. This study aimed to comprehensively assess the diagnostic value of AFR as single markers or in combination with squamous cell carcinoma antigen (SCC-Ag), cancer antigen 125 (CA-125) in cervical cancer.
A total of 323 cervical cancer inpatients, 143 patients with cervical intraepithelial neoplasia (CIN) and 317 healthy controls were analyzed. Differences in laboratory parameters and clinicopathological features were calculated using the Mann-Whitney U or Kruskal-Wallis H test. The receiver operating characteristic (ROC) curve was used to evaluate the predicted value of AFR, alone or combined with SCC-Ag, CA-125 for the diagnosis of cervical cancer.
The levels of AFR in patients with cervical cancer were significantly lower than those in the CIN patients and the control subjects. AFR were not only negatively correlated with the tumor stage, but also related to histology typing, lymph node metastasis, distant metastasis, depth of stromal infiltration, tumor size, and tumor stage; however, it was not associated with the blood group. AFR combined with SCC-Ag possessed a larger area under the curve (AUC; AUC = 0.924, 95% confidence interval (CI) 0.900, 0.944) than AFR ( < 0.001), SCC-Ag ( < 0.001), or CA-125 ( < 0.001) did alone.
The pretreatment levels of AFR, alone or combined with SCC-Ag, CA-125 could improve the diagnostic efficiency of cervical cancer.
白蛋白与纤维蛋白原比值（AFR）在许多恶性肿瘤的进展和预后中起着至关重要的作用。本研究旨在全面评估 AFR 作为单一标志物或与鳞状细胞癌抗原（SCC-Ag）、癌抗原 125（CA-125）联合用于宫颈癌的诊断价值。
共分析了 323 例宫颈癌住院患者、143 例宫颈上皮内瘤变（CIN）患者和 317 例健康对照者的实验室参数和临床病理特征。采用 Mann-Whitney U 或 Kruskal-Wallis H 检验计算差异。使用受试者工作特征（ROC）曲线评估 AFR 单独或与 SCC-Ag、CA-125 联合用于诊断宫颈癌的预测值。
宫颈癌患者的 AFR 水平明显低于 CIN 患者和对照组。AFR 不仅与肿瘤分期呈负相关，还与组织学类型、淋巴结转移、远处转移、间质浸润深度、肿瘤大小和肿瘤分期有关；然而，与血型无关。AFR 联合 SCC-Ag 的曲线下面积（AUC；AUC = 0.924，95%置信区间（CI）0.900，0.944）大于 AFR（<0.001）、SCC-Ag（<0.001）或 CA-125（<0.001）单独使用。
治疗前 AFR 水平，单独或联合 SCC-Ag、CA-125，可提高宫颈癌的诊断效率。
