Gynecology and Obstetrics Service, Hospital Álvarez Buylla. Asturias, Spain.
Schoool of Medicine, Universidad de Oviedo. Asturias, Spain.
Rev Colomb Obstet Ginecol. 2024 Mar 20;75(1):4046. doi: 10.18597/rcog.4046.
To determine if there is an association between the neutrophil to lymphocyte ratio (NLR) and prognosis in patients with epithelial ovarian cancer (EOC) diagnosed and treated in a Spanish population.
Retrospective cohort of patients with epithelial ovarian cancer who had neutrophil and lymphocyte values in complete blood count before the histopathological diagnosis and survival of at least three months, in an intermediate complexity hospital. Convenience sampling. Measured variables included age, menopausal stage, parity, International Federation of Gynecology and Obstetrics (FIGO) stage, treatment type, residual tumor, lymph node involvement, presence of ascites, cytology, histologic type, differentiation grade, and CA-125 values. Additionally, outcomes, overall survival, disease/progression-free survival were also measured. Bivariate inferential and Cox regression analyses were performed.
Out of 78 candidates, 60 women with EOC were included. Of them, 24 (40%) had a low NLR (≤ 2,9) while 36 (60%) had a high NLR (> 2,9). An association was found between high NLR levels and suboptimal cytoreductive surgery. High NLR ratios were associated with lower overall survival (Hazard ratio (HR): 4.1; 95% CI: 1.4-11.8) and lower 5-year disease-free survival (HR: 2.6; 95% CI: 1.2-5.7).
A plasma neutrophil to lymphocyte ratio of more than 2.9 was associated with poor prognosis in patients with epithelial ovarian cancer in our setting. There is a need to establish the optimal cut-off point and conduct prospective studies with larger patient numbers in order to support this information.
确定中性粒细胞与淋巴细胞比值（NLR）与在西班牙人群中诊断和治疗的上皮性卵巢癌（EOC）患者的预后是否存在关联。
这是一项回顾性队列研究，纳入了在一家中等复杂程度的医院中接受组织病理学诊断且至少有 3 个月生存时间的上皮性卵巢癌患者，这些患者在全血细胞计数中有中性粒细胞和淋巴细胞值。采用便利抽样法。测量的变量包括年龄、绝经状态、产次、国际妇产科联合会（FIGO）分期、治疗类型、残余肿瘤、淋巴结受累、腹水存在、细胞学、组织学类型、分化程度和 CA-125 值。此外，还测量了结局、总生存期和无病/进展生存期。进行了双变量推断和 Cox 回归分析。
在 78 名候选者中，纳入了 60 名患有 EOC 的女性。其中，24 名（40%）患者 NLR 较低（≤2.9），36 名（60%）患者 NLR 较高（>2.9）。高水平 NLR 与次优减瘤手术有关。高水平 NLR 与总生存期降低相关（风险比（HR）：4.1；95%置信区间（CI）：1.4-11.8），5 年无病生存率降低（HR：2.6；95%CI：1.2-5.7）。
在我们的研究环境中，超过 2.9 的血浆中性粒细胞与淋巴细胞比值与上皮性卵巢癌患者的不良预后相关。需要确定最佳截止值，并进行前瞻性研究，纳入更多患者，以支持这一信息。
