Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Surg Pathol Clin. 2020 Jun;13(2):267-276. doi: 10.1016/j.path.2020.02.001. Epub 2020 Apr 7.
Primary lymphoid neoplasms of the central nervous system are rare tumors that span a wide range of histopathologic appearances and can overlap occasionally with non-neoplastic processes. Application of modern molecular techniques has not only begun to unravel their unique underlying biology but has also started to lay a valuable diagnostic and therapeutic framework for these frequently aggressive malignancies. This review summarizes the existing landscape of clinicopathologic and genomic features of lymphoid neoplasms that may arise primarily within the central nervous system.
原发性中枢神经系统淋巴肿瘤较为罕见，其组织病理学表现多样，偶尔与非肿瘤过程重叠。现代分子技术的应用不仅开始揭示其独特的潜在生物学特性，而且还为这些频繁侵袭性恶性肿瘤奠定了有价值的诊断和治疗框架。本综述总结了原发性中枢神经系统淋巴肿瘤的临床病理和基因组特征的现有研究进展。
