Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
Mech Ageing Dev. 2020 Jun;188:111251. doi: 10.1016/j.mad.2020.111251. Epub 2020 May 7.
Sestrins (Sesns) represent a highly conserved family of stress-inducing proteins that are involved in antioxidant and autophagy regulatory functions. They are very important mediators as they can protect the cells under a variety of noxious stimulating conditions. However, the functions of Sesns in aging has not yet been fully understood. Here, we summarize the roles of Sesns in the aging process. A series of studies have shown that Sesns are highly involved in the aging process by regulating the nutritional perception, metabolic homeostasis, immunity, autophagy, lifespan and health span. The details of how Sesns act on them will be described in this review. Due to the conservation of their function during evolution, Sesns may be used as novel targets for aging intervention and also provide new strategies for anti-aging treatment.
Sestrins（Sesns）代表了一组高度保守的应激诱导蛋白家族，它们参与抗氧化和自噬调节功能。它们是非常重要的介质，因为它们可以在多种有害刺激条件下保护细胞。然而，Sesns 在衰老过程中的作用尚未完全理解。在这里，我们总结了 Sesns 在衰老过程中的作用。一系列研究表明，Sesns 通过调节营养感知、代谢稳态、免疫、自噬、寿命和健康跨度，高度参与衰老过程。Sesns 如何对它们起作用的细节将在本综述中描述。由于它们在进化过程中的功能保守性，Sesns 可能被用作衰老干预的新靶点，并为抗衰老治疗提供新策略。
