Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, China.
Department of Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, China.
Biogerontology. 2024 Feb;25(1):9-22. doi: 10.1007/s10522-023-10053-y. Epub 2023 Jul 30.
Sestrins are a type of highly conserved stress-inducing protein that has antioxidant and mTORC1 inhibitory functions. Metabolic dysfunction and aging are the main risk factors for development of human diseases, such as diabetes, neurodegenerative diseases, and cancer. Sestrins have important roles in regulating glucose and lipid metabolism, anti-tumor functions, and aging by inhibiting the reactive oxygen species and mechanistic target of rapamycin complex 1 pathways. In this review, the structure and biological functions of sestrins are summarized, and how sestrins are activated and contribute to regulation of the downstream signal pathways of metabolic and aging-related diseases are discussed in detail with the goal of providing new ideas and therapeutic targets for the treatment of related diseases.
Sestrins 是一种高度保守的应激诱导蛋白，具有抗氧化和 mTORC1 抑制功能。代谢功能障碍和衰老是人类疾病发展的主要危险因素，如糖尿病、神经退行性疾病和癌症。Sestrins 通过抑制活性氧和雷帕霉素靶蛋白复合物 1 途径，在调节葡萄糖和脂质代谢、抗肿瘤功能和衰老方面发挥着重要作用。本综述总结了 sestrins 的结构和生物学功能，并详细讨论了 sestrins 的激活及其对代谢和衰老相关疾病下游信号通路的调节作用，以期为相关疾病的治疗提供新的思路和治疗靶点。
