Dekant Wolfgang
Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany.
Toxicol Lett. 2020 May 7;330:1-6. doi: 10.1016/j.toxlet.2020.05.003.
The European Food Safety Authority (EFSA) has developed a group tolerable daily intake (TDI) for low molecular weight phthalates (LWP) including diisononyl phthalate (DINP). The LWP covered by the group TDI induce clear adverse effects on rat testicular development and pronounced reductions in fetal testicular testosterone. In contrast, DINP has a very low potency regarding changes in testicular testosterone in fetal rodents and does not induce adverse effects on reproductive endpoints. The most sensitive toxicity endpoint for DINP is liver toxicity. Due to the much lower potency of DINP for effects on testosterone, absence of reproductive toxicity, and its noted liver toxicity as compared to the LWP in the group, DINP should not be included in the group TDI.
欧洲食品安全局（EFSA）已制定了包括邻苯二甲酸二异壬酯（DINP）在内的低分子量邻苯二甲酸盐（LWP）的群体每日耐受摄入量（TDI）。该群体TDI所涵盖的LWP对大鼠睾丸发育有明显的不良影响，并使胎儿睾丸睾酮显著降低。相比之下，DINP对胎儿啮齿动物睾丸睾酮变化的影响效力非常低，且不会对生殖终点产生不良影响。DINP最敏感的毒性终点是肝脏毒性。由于与该群体中的LWP相比，DINP对睾酮的影响效力低得多，不存在生殖毒性，且具有明显的肝脏毒性，因此DINP不应纳入群体TDI中。
