MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, 48824, USA; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.
MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, 48824, USA; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA; Department of Plant Biology, Michigan State University, East Lansing, MI, 48824, USA.
Biochimie. 2020 Nov;178:15-25. doi: 10.1016/j.biochi.2020.04.022. Epub 2020 May 7.
Microalgae are single-cell, photosynthetic organisms whose biodiversity places them at the forefront of biological producers of high-value molecules including lipids and pigments. Some of these organisms particular are capable of synthesizing n-3 very long chain polyunsaturated fatty acids (VLC-PUFAs), known to have beneficial effects on human health. Indeed, VLC-PUFAs are the precursors of many signaling molecules in humans involved in the complexities of inflammatory processes. This mini-review provides an inventory of knowledge on the synthesis of VLC-PUFAs in microalgae and on the diversity of signaling molecules (prostanoids, leukotrienes, SPMs, EFOX, isoprostanoids) that arise in humans from VLC-PUFAs.
微藻是单细胞、光合作用的生物体，其生物多样性使它们成为高价值分子（包括脂质和色素）的生物生产者的前沿。其中一些生物体特别能够合成 n-3 长链多不饱和脂肪酸（VLC-PUFAs），已知对人类健康有有益的影响。事实上，VLC-PUFAs 是人类中许多参与炎症过程复杂性的信号分子的前体。本综述提供了关于微藻中 VLC-PUFAs 合成以及人类中由 VLC-PUFAs 产生的信号分子（前列腺素、白三烯、SPM、EFOX、异前列腺素）多样性的知识清单。
