Fernández O, Aladro Y, Arroyo R, Brieva Ll, Calles-Hernández M C, Carrascal P, Comabella M, Costa-Frossard L, Eichau S, García-Merino J A, Ginestal R, González I, Izquierdo G, Martínez-Ginés M L, Meca-Lallana J E, Mendibe-Bilbao M M, Oterino A, Prieto J M, Río J, Ramió-Torrentà Ll, Romero-Pinel L, Téllez N, Rodríguez-Antigüedad A
Instituto de Investigación Biomédica de Málaga. IBIMA, Málaga, España.
Hospital Universitario de Getafe, 28905 Getafe, España.
Rev Neurol. 2020 May 16;70(10):379-390. doi: 10.33588/rn.7010.2020121.
Like every year, after the ECTRIMS Congress, renowned Spanish neurologists who are experts in multiple sclerosis presented the main novelties in research in this field at the Post-ECTRIMS Meeting.
To summarise the content presented at the 12th edition of the Post-ECTRIMS Meeting, which took place in September 2019 in Sevilla and is presented in two parts.
This first part addresses the latest studies on vitamin D deficiency and the discrepancies that currently exist regarding its treatment. The advances made in epigenetics allow us to present this approach as a possible biomarker of multiple sclerosis. An account is provided to explain the growing importance of imaging techniques to detect atrophy and other phenomena that occur during the disease, such as changes in iron concentration or remyelination processes, which allow us to further our understanding of the mechanisms of cortical pathology, and the dimensionality of neurodegeneration during its course. Findings related to immunological mechanisms and advances in potential antigen-specific therapies are discussed. The contribution presents the latest studies on the assessment of cognitive impairment and its rehabilitation, which are becoming increasingly important due to the high prevalence of these disorders and the absence of their systematic assessment in clinical practice. Finally, the unmet social and health needs of multiple sclerosis patients in our country are presented, with emphasis on the current deficits in the system of social protection.
与往年一样，在ECTRIMS大会之后，西班牙著名的多发性硬化症专家神经科医生在ECTRIMS会后会议上介绍了该领域研究的主要新进展。
总结于2019年9月在塞维利亚举行的第12届ECTRIMS会后会议上所展示的内容，该内容分为两部分呈现。
第一部分论述了维生素D缺乏症的最新研究以及目前在其治疗方面存在的差异。表观遗传学方面取得的进展使我们能够将这种方法作为多发性硬化症的一种可能的生物标志物来呈现。阐述了成像技术在检测疾病过程中出现的萎缩及其他现象（如铁浓度变化或再髓鞘化过程）方面日益增长的重要性，这使我们能够进一步了解皮质病理机制以及疾病过程中神经变性的维度。讨论了与免疫机制相关的发现以及潜在抗原特异性疗法的进展。该报告展示了关于认知障碍评估及其康复的最新研究，由于这些疾病的高患病率以及临床实践中缺乏对其系统评估，这些研究正变得越来越重要。最后，介绍了我国多发性硬化症患者未得到满足的社会和健康需求，重点强调了社会保护体系目前存在的不足。
