Grin Leonti, Girsh Eliezer, Harlev Avi
Fertility and IVF Unit, Department of Obstetrics and Gynecology, Barzilai University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Andrologia. 2021 Mar;53(2):e13635. doi: 10.1111/and.13635. Epub 2020 May 11.
Male fertility preservation has been steadily increasing over the past two decades. Significant improvements have been achieved in the treatment modalities of cancer and other severe chronic medical conditions, leading to an increase in patient survivorship and the resulting demand for future parenthood. Recognition and proper patient counselling before commencing therapies with a potential gonadotoxic effect are of paramount importance. Similarly, nonmedically indicated fertility preservation is on the rise. Social sperm banking, gender dysphoria prior to affirmation procedures and posthumous reproduction preservation are becoming more common. When timing and logistics are appropriate, sperm cryopreservation is considered the gold standard for fertility preservation. Testicular tissue and spermatogonial stem cell autotransplantation is considered experimental and represents a promising alternative for pre-pubertal patients. The current paper aims to review the recent trends in male fertility preservation, the common indications for sperm cryopreservation, techniques for sperm retrieval and experimental frontiers.
在过去二十年中，男性生育力保存一直在稳步增加。癌症和其他严重慢性疾病的治疗方式取得了显著进展，导致患者存活率提高，进而产生了对未来生育的需求。在开始使用具有潜在性腺毒性作用的治疗方法之前，认识到这一点并对患者进行适当的咨询至关重要。同样，非医学指征的生育力保存也在增加。社会精子库、性别肯定程序前的性别焦虑症以及死后生殖保存变得越来越普遍。当时间和后勤条件合适时，精子冷冻保存被认为是生育力保存的金标准。睾丸组织和精原干细胞自体移植被认为是实验性的，是青春期前患者的一种有前途的替代方法。本文旨在综述男性生育力保存的最新趋势、精子冷冻保存的常见指征、精子采集技术和实验前沿。
