Sharif Alireza, Haddad Kashani Hamed, Sharif Mohammad Reza
1Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
2Anatomical Sciences Research Center, Basic Sciences Research Institute, Kashan University of Medical Sciences, Kashan, Iran.
Clin Mol Allergy. 2020 May 4;18:7. doi: 10.1186/s12948-020-00122-9. eCollection 2020.
Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma remains uncertain. In this study, the associations of 25(OH) vit. D levels with asthma and with the severity of asthma were evaluated.
This was a case-control study performed in 2015 in the city of Isfahan. In this study 520 children were studied. Children with asthma were classified as cases and children who were referred for reasons other than respiratory problems and asthma were considered as controls. Serum 25 (OH) vit. D levels were then examined and compared between the two groups. Differences among groups were stated to be statistically significant when -values < 0.05.
There were 260 asthmatic children and 260 controls in the present study. The mean 25 (OH) vit. D levels in the case group was 25.5 ± 16.62 and 16.76 ± 31.40 the control group and this difference was statistically significant (P < 0.05). 25(OH) vit. D levels were found to be 28.05 ± 16.98 in non-severe asthma and 21.41 ± 15.20 in severe asthma. Consequently 25(OH) vit. D level had inverse relationship with asthma severity (P = 0.002).
As the results of this study showed, the lower level of 25(OH) vit. D correlated with the higher severity of asthma manifestations. Therefore, it is recommended that 25(OH) vit. D levels get routinely checked especially in severe asthma cases and if the deficiency presents, appropriate therapeutic measures be used to reduce the asthma severity.
哮喘在全球范围内都有很高的患病率，这引发了众多关于其病因的研究。尽管对哮喘进行了广泛研究，但25-羟基维生素D（25(OH)维生素D）与哮喘之间的关联仍不明确。在本研究中，评估了25(OH)维生素D水平与哮喘及其严重程度之间的关联。
这是一项于2015年在伊斯法罕市进行的病例对照研究。本研究共纳入520名儿童。患有哮喘的儿童被分类为病例组，因呼吸问题和哮喘以外的原因就诊的儿童被视为对照组。然后检测并比较两组儿童的血清25(OH)维生素D水平。当P值<0.05时，组间差异被认为具有统计学意义。
本研究中有260名哮喘儿童和260名对照组儿童。病例组的平均25(OH)维生素D水平为25.5±16.62，对照组为16.76±31.40，这一差异具有统计学意义（P<0.05）。非重度哮喘患者的25(OH)维生素D水平为28.05±16.98，重度哮喘患者为21.41±15.20。因此，25(OH)维生素D水平与哮喘严重程度呈负相关（P=0.002）。
正如本研究结果所示，25(OH)维生素D水平较低与哮喘表现的严重程度较高相关。因此，建议常规检测25(OH)维生素D水平，尤其是在重度哮喘病例中，如果存在维生素D缺乏，应采取适当的治疗措施以减轻哮喘严重程度。
