Menon Jennifer, Maranda Louise, Nwosu Benjamin U
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA.
J Pediatr Endocrinol Metab. 2012;25(7-8):673-9. doi: 10.1515/jpem-2012-0143.
There is no consensus on the association between vitamin D and asthma.
To determine the relationship between 25-hydroxyvitamin D [25(OH)D] levels and asthma symptom severity in children and adolescents.
A retrospective, case-control study of 263 subjects of ages 2-19 years with asthma who were compared to 284 non-asthmatic controls of similar ages. Subjects were excluded if they had diseases of calcium or vitamin D metabolism or were receiving calcium or vitamin D supplementation. Serum 25(OH)D was measured in all subjects. Asthma symptom severity, usually stratified into 6 steps, was stratified into five steps [1-5] based on the number and dose of controller medications used as outlined by the National Heart, Lung, and Blood Institute's guidelines. Mean 25(OH)D values were compared between the asthmatic patients and controls, as well as among the five steps of asthma symptom severity. Results were adjusted for age, sex, BMI, race and severity of asthma symptoms.
There was no difference in 25(OH)D between asthmatic patients and controls (28.64 +/- 10.09 vs. 28.42 +/- 11.47, p = 1.0). However, there was a significant difference in 25(OH)D between obese and non-obese asthmatic patients (23.33 +/- 7.67 vs. 30.16 +/- 10.20, p < 0.0001), as well as obese and non-obese controls (24.56 +/- 9.90 vs. 29.50 +/- 11.66, p = 0.003). Mean 25(OH)D levels did not vary significantly among the five steps of asthma symptom severity.
There were no differences in mean 25(OH) D levels between asthmatic patients and controls. Mean 25(OH)D level was significantly lower in both the obese asthmatic patients and obese controls. Asthma severity had no relationship to mean 25(OH)D levels.
维生素D与哮喘之间的关联尚无定论。
确定儿童和青少年25-羟维生素D[25(OH)D]水平与哮喘症状严重程度之间的关系。
一项回顾性病例对照研究，纳入263名2至19岁的哮喘患者，并与284名年龄相仿的非哮喘对照者进行比较。如果受试者患有钙或维生素D代谢疾病或正在接受钙或维生素D补充剂，则将其排除。对所有受试者测量血清25(OH)D。哮喘症状严重程度通常分为6级，根据美国国立心肺血液研究所指南中使用的控制药物数量和剂量分为五级[1-5]。比较哮喘患者和对照者之间以及哮喘症状严重程度五级之间的平均25(OH)D值。结果根据年龄、性别、BMI、种族和哮喘症状严重程度进行了调整。
哮喘患者和对照者之间的25(OH)D无差异(28.64±10.09 vs. 28.42±11.47，p = 1.0)。然而，肥胖和非肥胖哮喘患者之间的25(OH)D存在显著差异(23.33±7.67 vs. 30.16±10.20，p < 0.0001)，肥胖和非肥胖对照者之间也存在显著差异(24.56±9.90 vs. 29.50±11.66，p = 0.003)。哮喘症状严重程度五级之间的平均25(OH)D水平无显著差异。
哮喘患者和对照者之间的平均25(OH)D水平无差异。肥胖哮喘患者和肥胖对照者的平均25(OH)D水平均显著较低。哮喘严重程度与平均25(OH)D水平无关。
