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中医:在减少阿尔茨海默病的β-淀粉样蛋白、细胞凋亡、自噬、神经炎症、氧化应激和线粒体功能障碍方面的作用

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer's Disease.

作者信息

Chen Shi-Yu, Gao Yue, Sun Jia-Yi, Meng Xian-Li, Yang Dong, Fan Lin-Hong, Xiang Li, Wang Ping

机构信息

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Pharmacol. 2020 Apr 22;11:497. doi: 10.3389/fphar.2020.00497. eCollection 2020.

Abstract

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease characterized by memory loss and cognitive impairment. The major characteristics of AD are amyloid β plaques, apoptosis, autophagy dysfunction, neuroinflammation, oxidative stress, and mitochondrial dysfunction. These are mostly used as the significant indicators for selecting the effects of potential drugs. It is imperative to explain AD pathogenesis and realize productive treatments. Although the currently used chemical drugs for clinical applications of AD are effective in managing the symptoms, they are inadequate to achieve anticipated preventive or therapeutic outcomes. There are new strategies for treating AD. Traditional Chinese Medicine (TCM) has accumulated thousands of years of experience in treating dementia. Nowadays, numerous modern pharmacological studies have verified the efficacy of many bioactive ingredients isolated from TCM for AD treatment. In this review, representative TCM for the treatment of AD are discussed, and among these herbal medicines, the Lamiaceae family accounts for the highest proportion. It is concluded that monomers and extracts from TCM have potential therapeutic effect for AD treatment.

摘要

阿尔茨海默病(AD)是一种与年龄相关的进行性神经退行性疾病,其特征为记忆力丧失和认知障碍。AD的主要特征包括淀粉样β斑块、细胞凋亡、自噬功能障碍、神经炎症、氧化应激和线粒体功能障碍。这些大多被用作选择潜在药物疗效的重要指标。解释AD发病机制并实现有效治疗势在必行。尽管目前用于AD临床应用的化学药物在控制症状方面有效,但它们不足以实现预期的预防或治疗效果。治疗AD有新的策略。中医在治疗痴呆方面积累了数千年的经验。如今,众多现代药理学研究已证实从中药中分离出的许多生物活性成分对AD治疗的有效性。在本综述中,讨论了用于治疗AD的代表性中药,其中唇形科植物占比最高。得出的结论是,中药单体和提取物对AD治疗具有潜在的治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7188934/0ab654034287/fphar-11-00497-g001.jpg

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